The Effect of Proprioception of Platelet Rich Plasma for Patients With Ankle Sprain
- Conditions
- Ankle Sprain 2Nd DegreeAnkle Sprain 3Rd Degree
- Interventions
- Registration Number
- NCT03808454
- Lead Sponsor
- National Defense Medical Center, Taiwan
- Brief Summary
Ankle sprain is a fairly common sports medicine clinic. In Taiwan at least 150,000 to 200,000 people will suffer from ankle sprains every years. Clinicians have been looking for ways to shorten treatment time and reduce discomfort. Platelet Rich Plasma(PRP) is an endogenous therapeutic technology that involved in regenerative medicine due to its potential to stimulate and accelerate tissue healing. PRP can release lots of growth factors like platelet-derived growth factor (PDGF),transforming Growth Factor Beta(TGF-β), vascular endothelial growth factor(VEGF),Epidermal growth factor(EGF) and insulin-like growth factor (IGF). Its use had been based on the theory that increased autologous platelets, that then yield high concentrations of growth factors and other proteins, will lead to increased healing of tendon and soft tissue on a cellular level. In addition, there is no objective evaluation after treatment, so that patients can not provide effective and accurate quantitative feedback. In this study, the investigators divided patients into three groups, respectively, general rehabilitation therapy, autologous PRP injection therapy, autologous PRP injection combined with general rehabilitation therapy.
- Detailed Description
The investigators divided patients into three groups, respectively, general rehabilitation therapy, autologous PRP injection therapy, autologous PRP injection combined with general rehabilitation therapy randomly. The investigators also use the new ankle proprioception evaluation system and evaluation of clinical function after treatment. It is expected to establish another feasible and rapid treatment method for ankle sprain. Combined with high accuracy ankle body defect evaluation method, it is helpful to design proper treatment and rehabilitation strategy in the future so as to improve the rehabilitation of limbs Coordination and control capabilities.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 60
- ankle sprain within one months
- Gr II or Gr III ankle sprain (anterior talus fibular ligament)by sonogram proved
- MMSE≥23
- could cooperate the examination of the test
- Hemianopsia or hemineglect any brain lesion such as cerebrum of cerebellum involved movement
- cancer victim
- pregnant If needed PRP treatment
- Liver cirrhosis
- Platelet < 150000/UL
- Sepsis, Leukemia
- use anti-coagulation agents
- under hemodialysis
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Platelet rich plasma (PRP) PRP PRP injection only PRP+Rehabilitation PRP+Rehabilitation PRP injection combined with rehabilitation Rehabilitation Rehabilitation Rehabilitation treatment only
- Primary Outcome Measures
Name Time Method mean of the distance of ankle movement by the force plate system 10 min The proprioception could be evaluated by the parameter of mean of the distance of ankle movement by the force plate system
standard error 10 min evaluated by the parameter of standard error of the distance of ankle movement by the force plate system
coefficient of variance 10 min evaluated by the parameter of coefficient of variance of the distance of ankle movement by the force plate system
- Secondary Outcome Measures
Name Time Method Time Up and Go(TUG) 15 sec walking ability
Visual analogues scale (VAS ) 5 sec pain level
AOFAS Ankle-Hindfoot score 10 min function of ankle and foot
Trial Locations
- Locations (1)
Tri-service General Hospital
🇨🇳Taipei, Taiwan
Tri-service General Hospital🇨🇳Taipei, TaiwanDepartment of RehabilitationContact