Clinical Trial: Evaluation of 2 Different Protocols of Blood Derivates Transfusion in Acute Trauma Patients in a Brazilian Tertiary Hospital

In this randomized trial trauma patients in need of massive transfusion will be assigned to one of the following transfusion strategies:

1. • Fresh Frozen Plasma, Platelets Concentrate and Packed red blood cells in 1:1:1 ratio.
2. • These patients will receive Red blood cells based on Haemoglobin measurements and will receive either Beriplex® P/N (CSL Behring GmbH, Marburg, Germany) or Haemocomplettan® P (CSL Behring, Marburg, Germany), or Platelets based on thromboelastometry.

To be included patients must meet the following inclusion criteria:

1. • Trauma victims
2. • Adults between 18 - 80 years old
3. • Injury Severity Score (ISS) between 15 and 45
4. • Assessment of Blood Consumption (ABC) Score ≥ 3 points
5. • Shock Index ≥ 1,2
6. • Acute hemorrhage of more than 50% estimated blood volume in 3 hours or more than 1,5 ml/kg/min of blood during 20 minutes.

Exclusion Criteria: