Exploring the Possible Beneficial Impact of Non-invasive and Invasive Neuromodulation on Freezing of Gait in Parkinson's Disease During Different Ambulatory Complexities: An Electrophysiological and fMRI Study
- Conditions
- Transcranial Direct Current Stimulation
- Registration Number
- NCT06505460
- Lead Sponsor
- China Medical University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria:<br><br> 1. Patients meet the diagnosis of PD based on the established consensus criteria<br><br> 2. Age above 20 years old and below 90 years<br><br> 3. For MRgFUS patients: a. At least one of the 3 cardinal symptoms (akinesia, tremor,<br> rigidity) reaches an intensity of at least 2/4. b. Parkinsonian symptoms cannot be<br> satisfactorily controlled by optimal pharmacological treatment including L-dopa and<br> other antiparkinsonian drugs. c. stable medication for PD = 30 days.<br><br> 4. DBS patients must meet Taiwan Health Insurance criteria: PD duration exceeding 5<br> years, positive response to levodopa (=33% UPDRS motor score improvement), and<br> presence of motor complications (e.g., wearing off, on-off, levodopa-related<br> dyskinesia, or medically intractable tremor).<br><br>Exclusion Criteria:<br><br> 1. Congestive heart failure (Functional III or above) or advanced cancer with distant<br> metastasis.<br><br> 2. PD at Hoehn and Yahr Stage 5.<br><br> 3. DBS exclusion criteria: overt dementia or major depression.
Not provided
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Electroencephalogram recording before and after the tDCS session;Electromyography recording before and after the tDCS session;Functional magnetic resonance images examination before and after the tDCS session;Change in Unified Parkinson's Disease Rating Scale (UPDRS) Part III before and after the tDCS session UPDRS contains four parts, the third part of which is reported in this outcome.
- Secondary Outcome Measures
Name Time Method Change in New freezing of gait questionnaire (NFOG-Q) before and after the tDCS session;Change in Gait and Falls Questionnaire (GFQ) before and after the tDCS session