The Bern Perioperative Biobank

Completed

• Conditions: Anesthesia; Surgical Procedure, Operative

• Registration Number: NCT04767685
• Lead Sponsor: Insel Gruppe AG, University Hospital Bern

Brief Summary

The goal of the research is to define clinically relevant molecular markers for increased risk of peri-/ postoperative organo-dysfunctions, inflammation, adverse events and disease progression. To better understand the perioperative impact the investigators aim to determine perioperative levels of molecular markers over time in the available samples and clinical data of the Bern perioperative Biobank (BPBB) cohort to finally increase quality of perioperative care of patients by permitting preventive measures to be taken early in patients at risk.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-01
• Study First Submitted: 2020-12-16
• Study First Submitted QC: 2021-02-22
• Study First Posted: 2021-02-23
• Primary Completion: 2021-12
• Study Completion: 2021-12
• Status Verified: 2022-11
• Last Update Submitted: 2022-11-14
• Last Update Posted: 2022-11-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 547

Inclusion Criteria

• 18 years and older
• Written informed consent
• Non-emergency surgery

Exclusion Criteria

• Transient incapacity to consent or insufficient time (< 6h) to consider study participation
• No informed consent
• Cognitive impairment/Patients unable to consent
• Patients who retrospectively expressed their wish to be excluded

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Assessing the change of the metabolic profile in the perioperative setting	On postoperative day 1 during the morning round between 07:30-9:00am	Surgery causes significant disruption of physiologic metabolism. The investigators currently lack specific markers to assess change of the metabolic profile in the perioperative setting. The investigators aim to identify metabolic markers and their change in the perioperative period in association with patients' clinical outcome.

Trial Locations

Locations (1)

Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern; 🇨🇭 Bern, Switzerland