Placebo-controlled double-blinded parallel randomized study to test the urate-lowering effect of yogurt containing Lactobacillus gasseri PA-3 in adult males with marginal hyperuricemia

Not Applicable

• Conditions: Healthy male adult

• Registration Number: JPRN-UMIN000021069
• Lead Sponsor: Tsukuba International Clinical Pharmacology Clinic

Brief Summary

The results of the analysis after excluding the data with purine intake of over 450 mg/day have shown that serum urate of the high-concentration group was significantly lower than the placebo group at week 2 (P = 0.025), and the linear regression analysis has indicated a dose-dependent decrease of serum urate ( P = 0.046). The equivalent analysis using the data at week 8 also showed that serum urate of the high-concentration group was significantly lower than the placebo group (P = 0.031), and the linear regression analysis indicated a dose-dependent decrease of serum urate ( P = 0.021). Those data suggest that yogurt containing L. gasseri PA-3 lower serum urate.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-02-17
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: Male
• Target Recruitment: 60

Inclusion Criteria

Not provided

Exclusion Criteria

1.Subjects with Phamacotherapy,Exercise therapy and Medical diet of hyperuricemia(gout). 2.Subjects with a history of gout or hyperuricemia. 3.Subjects with a using healthy food about hyperuricemia commonly. 4.Subjects who are judged ineligible by the principal investigator or subinvestigator.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum uric acid level

Secondary Outcome Measures

Name	Time	Method
rine uric acid level