Health At Every Size and Acceptance and Commitment Therapy vs. Behavioral Weight Loss for Obesity and Depression in Women
- Conditions
- DepressionObesity
- Interventions
- Behavioral: Accept Yourself!Behavioral: Weight Watchers
- Registration Number
- NCT02501239
- Lead Sponsor
- Dartmouth-Hitchcock Medical Center
- Brief Summary
The primary aim of this project is to conduct a randomized controlled pilot study evaluating the feasibility and potential effectiveness of a newly developed combined Health At Every Size and Acceptance and Commitment Therapy (HAES/ACT) treatment, known as Accept Yourself! compared to a commercial behavioral weight loss program, Weight Watchers (WW). Obese women (BMI ≥ 30) with Major Depressive Disorder will be randomly assigned to one of these two treatments. Depression, physical health, and other psychosocial outcomes will be assessed prior to treatment, at post-treatment, and at 3, 6, 9, and 12-month follow up assessments.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 19
- English-speaking
- Major Depressive Disorder (assessed using the Structured Clinical Interview for DSM-IV, SCID-IV)
- Body Mass Index (BMI) greater than or equal to 30
- Not taking medications or on stable medication regimens (i.e. no medication changes for six weeks prior to enrollment or during the study)
- current substance dependence
- history of psychotic symptoms
- high risk of suicide/self-harm
- current enrollment in a weight-loss program
- weight loss surgery in the past year
- current psychotherapy
- inability to postpone weight loss or depression treatment interventions for the duration of the study
- taking antipsychotic, tricyclic, or oral corticosteroid medication
- unwilling to be randomized to the study treatments
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Accept Yourself! Intervention Accept Yourself! Combined Health At Every Size and Acceptance and Commitment Therapy Psychotherapy Group Behavioral Weight Loss Weight Watchers Weight Watchers groups
- Primary Outcome Measures
Name Time Method Change in self-reported depression symptoms At post-treatment (immediately following the three-month intervention) and at 3, 6, 9, and 12-month follow-up assessments. As assessed by Patient Health Questionnaire-9 (PHQ-9)
Change in clinician assessed depression symptoms At post-treatment (immediately following the three-month intervention) and at 3, 6, 9, and 12-month follow-up assessments. As assessed by clinician rated Hamilton Depression Rating Scale (HAM-D)
- Secondary Outcome Measures
Name Time Method Change in cardiovascular fitness as assessed by six-minute walk test At post-treatment (immediately following the three-month intervention) and at 12-month follow-up. Change in systolic and diastolic blood pressure At post-treatment (immediately following the three-month intervention) and 12 month follow up Number of participants who did not complete an adequate dose of the intervention (at least 7 group visits) At post-treatment (immediately following the three-month intervention) Change in self-reported physical activity At post-treatment (immediately following the three-month intervention) and at 12-month follow-up. Change in fasting Lipids At post-treatment (immediately following the three-month intervention) and at 12 month follow-up. Change in fasting blood glucose At post-treatment (immediately following the three-month intervention) and 12 month follow up Change in eating disorder symptoms, measured by the Eating Disorders Diagnostic Scale (EDDS) At post-treatment (immediately following the three-month intervention) and at 3, 6, 9, and 12-month assessments. Change in obesity-related quality of life, measured by the Obesity-Related Well-Being Questionnaire (ORWELL97) At post-treatment (immediately following the three-month intervention) and at 3, 6, 9, and 12-month assessments. Change in obesity stigma, measured by the Weight Self-Stigma Questionnaire (WSSQ) At post-treatment (immediately following the three-month intervention) and at 3, 6, 9, and 12-month assessments. Change in weight At post-treatment (immediately following the three-month intervention) and 12 month follow up Note that we are assessing weight change primarily as a safety measure (i.e., to demonstrate no significant weight gain in intervention group).
Trial Locations
- Locations (1)
Dartmouth-Hitchcock Medical Center
🇺🇸Lebanon, New Hampshire, United States