Changing Thought and Action in Tobacco Dependence With Transcranial Magnetic Stimulation

Not Applicable

Completed

Conditions: Tobacco Dependence

Interventions: Device: repetitive transcranial magnetic stimulation (rTMS) 10 Hertz (Hz)
Device: repetitive transcranial magnetic stimulation (rTMS) 20Hz
Device: SHAM repetitive transcranial magnetic stimulation (rTMS)

Registration Number: NCT00973622

Lead Sponsor: University of Arkansas

Brief Summary: This study will examine the effects of high frequency, repetitive Transcranial Magnetic Stimulation (rTMS) on decision-making and smoking behavior.

Detailed Description: Tobacco use is the greatest cause of preventable death in the US and cigarette smokers exhibit substantial relapse following treatment. Understanding the brain mechanisms involved in tobacco dependence is an important step toward reducing the high rate of relapse associated with current behavioral and pharmacological treatments for smoking cessation. This study seeks to examine the effects of high frequency, repetitive Transcranial Magnetic Stimulation (rTMS) on decision-making and smoking behavior. A concept central to this study is that "quitting" tobacco necessitates making conscious choices not to smoke (to delay gratification) and these choices are influenced by the balance of activity between the frontal-parietal systems that process the value of rewards and limbic systems that are involved with immediate gratification. We aim to: 1) determine how two different levels of cortical excitation (10 Hz and 20Hz), induced by different rTMS frequencies, influence reward and risk-taking choices and cigarette consumption. Additionally, we aim to 2) determine how limbic activation due to acute nicotine withdrawal and/or satiation modifies the effects in aim 1. Twenty non-smoking and 20 smoking participants will receive two levels of high frequency rTMS and comparable sham stimulation (using electrical scalp stimulation) delivered over the left prefrontal cortex. Smokers will also crossover between nicotine satiation and acute withdrawal conditions to determine how rTMS interacts with limbic activation associated with nicotine use and withdrawal. In addition, changes in preattentional (brainstem-thalamus processing as measured using the P50 midlatency auditory evoked potential) and attentional (thalamocortical processing as measured using the Psychomotor Vigilance Task; PVT) will be assessed before and after treatment to quantitatively determine changes in preattentional/arousal and attentional function.

Recruitment & Eligibility

Status: COMPLETED

Sex: All

Target Recruitment: 66

Inclusion Criteria

Age 19-55
Must speak English
Must be right handed
Must pass the Transcranial Magnetic Stimulation Adult Safety and Screening Questionnaire (TAAS)
Smoking participants must be highly dependent with a score of 6 or greater on the Fagerstrom Test for Nicotine Dependence

Exclusion Criteria

Positive test for drugs of abuse
Positive pregnancy test
A personal or family history of epilepsy
A history of anticonvulsant medication use
A personal history of head injury
A history of aneurysm, stroke, or previous cranial neurosurgery
A diagnosis of bipolar disorder
A neurological or psychiatric disorder for which hospitalization was required
Tinnitus
Metal implants in the head, neck or cochlea
A pacemaker
Migraines
A history of taking medications that lower seizure threshold (i.e. such as tricyclic antidepressants or bupropion)
Claustrophobia (due to the MRI)
Used any form of tobacco in the past two years if they desire to be a non-smoking participant
Plans to quit smoking in the next 30 days if they desire to be a smoking participant
Current use of any medications for tobacco cessation (i.e. nicotine replacement, bupropion, varenicline, etc.)
A report of a high motivation to quit smoking (score 7 or great on the Motivation scale)

Study & Design

Study Type: INTERVENTIONAL

Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Smokers	repetitive transcranial magnetic stimulation (rTMS) 10 Hertz (Hz)	Healthy adult smokers aged 19-55 who are not currently interested in quitting smoking.
Smokers	repetitive transcranial magnetic stimulation (rTMS) 20Hz	Healthy adult smokers aged 19-55 who are not currently interested in quitting smoking.
Non-smokers	repetitive transcranial magnetic stimulation (rTMS) 20Hz	Healthy adult non-smokers aged 19-55
Smokers	SHAM repetitive transcranial magnetic stimulation (rTMS)	Healthy adult smokers aged 19-55 who are not currently interested in quitting smoking.
Non-smokers	SHAM repetitive transcranial magnetic stimulation (rTMS)	Healthy adult non-smokers aged 19-55
Non-smokers	repetitive transcranial magnetic stimulation (rTMS) 10 Hertz (Hz)	Healthy adult non-smokers aged 19-55

Primary Outcome Measures

Name	Time	Method
A Difference Score for the Log Value of K.	baseline and immediately after stimulation, an average of 25 seconds.	K is a output value, a summary statistic, derived from a hyperbolic function that summarizes the rate at which monetary values are discounted according to the time they are received. The value of K can either increase or decrease from its baseline value. For example, an increase in K would indicate that the participant is choosing to receive larger amounts of money at a later point in time. A decrease would suggest the opposite - lesser amounts of money at an earlier point in time). The difference score is calculated from baseline to that immediately after 10 or 20 Hz rTMS.

Secondary Outcome Measures