Effect of dexmedetomidine and remifentanil on perioperative glycaemic control in adult diabetic cardiac surgical patient requiring cardiopulmonary bypass:A Randomised controlled study

A total of 64 patients posted for elective coronary artery bypass ( CABG) surgery with history of diabetes mellitus will be randomly divided into two groups ( 32 each) group dexmedetomidine and group remifentanil. We will compare effective of dexmedetomidine and remifentanil in perioperative hyperglycaemia patients. Intraoperative blood glucose level will be kept less than 180 mg/dl using regular insulin as per vellore regimen, observations will recorded by an independent observer during the study period: (1) heart rate (HR), MAP, blood glucose level, and serum potassium level will noted at six different time points: before induction of anesthesia (T0), after sternotomy (T1), after establishment of CPB (T2), termination of CPB (T3), after transferring the patient to the intensive care unit (T4) and at 5th hour of the postoperative period (T5), (2) total insulin dose required to maintain the blood glucose levels <180 mg/dl during the study period, (3) hyperglycaemia episodes (blood glucose levels >180 mg/dl),  (4) incidence of postoperative arrhythmias and delirium till 72 hours after extubation.( 5) Sedation level and (6) incidence of stroke, myocardial ischemia, and mortality till discharge from hospital.