Sarcopenia and Physical fRailty IN Older People: Multi-componenT Treatment Strategies (SPRINTT)
试验速览
- 阶段
- 不适用
- 入组人数
- 1,500
- 试验地点
- 2
- 主要终点
- Incident of major mobility disability
研究概览
简要总结
The SPRINTT study will evaluate the efficacy of a multicomponent intervention programme (physical activity, nutritional counselling/dietary intervention, and information and communications technology intervention) compared with a healthy aging lifestyle education programme on mobility disability, in non-disabled older people with physical frailty and sarcopenia.
详细描述
As the life expectancy in European countries continues to increase, the maintenance of physical independence in older persons has become a major public health priority. The ability to ambulate without assistance is crucial for independent living and it is often the first ability to be lost in the process leading to disability. Older people who have impaired walking function need more assistance and are more likely to be placed in nursing homes, have a higher risk of morbidity, mortality and hospitalisation, and experience a reduced quality of life. The ultimate goals of the Sarcopenia and Physical fRailty IN older people: multicomponenT Treatment strategies (SPRINTT) project are to offer efficient treatment options, based on a multicomponent intervention including physical activity, nutrition and information and communications technology, to physically frail, sarcopenic older persons and to improve their quality of life. The result will directly contribute to the long-term sustainability and efficiency of health- and social-care systems. The conceptualisation of physical frailty and sarcopenia (PF&S) as proposed in SPRINTT will promote significant advancements over the traditional approaches by enabling the precise operationalisation of the condition, a clear identification of the affected population and the rapid translation of findings to the clinical arena.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 70 Years 至 —(Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Incident of major mobility disability
时间窗: 36 months
Incident inability to complete the 400-metre walk test (incidence of major mobility disability)
次要结局
- Changes in body mass index(36 months)
- Changes in mid-arm circumference(36 months)
- Changes in hip circumference(36 months)
- Changes in mood(36 months)
- Changes in lower extremity physical performance(36 months)
- Persistent mobility disability(36 months)
- Changes in nutritional status(36 months)
- Incidence of injurious falls(36 months)
- All-cause mortality(36 months)
- Changes in crude appendicular lean mass(36 months)
- Changes in upper extremity muscle strength(36 months)
- Changes in functional status (instrumental activities of daily living)(36 months)
- Changes in waist circumference(36 months)
- Changes in calf circumference(36 months)
- Changes in body mass index-adjusted appendicular lean mass(36 months)
- Changes in cognitive function(36 months)
- Changes in functional status (activities of daily living)(36 months)
- Changes in body weight(36 months)
- Incidence of self-reported falls(36 months)
- Changes in quality of life(36 months)
- Changes in the use of healthcare services(36 months)
- Cost effectiveness(36 months)
研究者
Roberto Bernabei
Professor of Geriatrics
Catholic University of the Sacred Heart
