NCT02003989已完成不适用
Revealing Increased Axonal Loss in Treated HIV Patients
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 156
- 试验地点
- 1
- 主要终点
- thickness of the RNFL and the RCGs measured by spectral domain OCT, between the two groups of patients
研究概览
简要总结
HIV patients may suffer sooner from aging than average population, including brain aging. Our hypothesis is that if brain dysfunctions are explained by a quicker loss of neurons in HIV patients, this loss could be detected earlier by a thinning down of retinal nerve fiber layer (RNFL), compared to non HIV patients of the same age.
详细描述
The investigators aim to compare the thickness of the RNFL and the thickness of the RCGs measured by spectral domain OCT between patients infected by HIV and patients of same age non infected by HIV.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •HIV infection known since at least 10 years
- •viral load undetectable under ARV treatment since at least 5 years, whatever the type of ARV
- •lymphocytes CD4 > 350, whatever the CD4 nadir
- •signed informed consent
排除标准
- •History of ocular pathology, eye surgery, or intraocular injection
- •Familial History of glaucoma
- •ametropia (>3 dioptres on the sphere and >1,5 dioptres on the cylinder)
- •known neurological pathology, active or former
- •History of ethambutol or synthetic antimalarial drug consumption
- •History of chemotherapy
- •Active and regular use of drugs
- •non-weaned chronic alcoholism
- •contra indication to MRI
- •cognitive disorders (MoCA<26)
- •non covered by health insurance
- •patient under legal protection
- •pregnant or breast-feeding woman
- •Non inclusion criteria for control patients: known HIV infection
结局指标
主要结局
thickness of the RNFL and the RCGs measured by spectral domain OCT, between the two groups of patients
时间窗: one day of examinations
次要结局
未报告次要终点
研究者
研究点 (1)
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