Revealing Increased Axonal Loss in Treated HIV Patients
Completed
- Conditions
- HIV Seropositivity
- Interventions
- Other: ophthalmologic examination and MRI
- Registration Number
- NCT02003989
- Lead Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
- Brief Summary
HIV patients may suffer sooner from aging than average population, including brain aging. Our hypothesis is that if brain dysfunctions are explained by a quicker loss of neurons in HIV patients, this loss could be detected earlier by a thinning down of retinal nerve fiber layer (RNFL), compared to non HIV patients of the same age.
- Detailed Description
The investigators aim to compare the thickness of the RNFL and the thickness of the RCGs measured by spectral domain OCT between patients infected by HIV and patients of same age non infected by HIV.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 156
Inclusion Criteria
- HIV infection known since at least 10 years
- viral load undetectable under ARV treatment since at least 5 years, whatever the type of ARV
- lymphocytes CD4 > 350, whatever the CD4 nadir
- signed informed consent
Exclusion Criteria
- History of ocular pathology, eye surgery, or intraocular injection
- Familial History of glaucoma
- ametropia (>3 dioptres on the sphere and >1,5 dioptres on the cylinder)
- known neurological pathology, active or former
- History of ethambutol or synthetic antimalarial drug consumption
- History of chemotherapy
- Active and regular use of drugs
- non-weaned chronic alcoholism
- contra indication to MRI
- diabetes
- cognitive disorders (MoCA<26)
- non covered by health insurance
- patient under legal protection
- pregnant or breast-feeding woman
- Non inclusion criteria for control patients: known HIV infection
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description control ophthalmologic examination and MRI non HIV patients (same gender and age) undergoing ophthalmologic examination and MRI patients ophthalmologic examination and MRI HIV patients infected for more than ten years with undetectable viral load, undergoing ophthalmologic examination and MRI
- Primary Outcome Measures
Name Time Method thickness of the RNFL and the RCGs measured by spectral domain OCT, between the two groups of patients one day of examinations
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Fondation OPH A de Rothschild
🇫🇷Paris, Ile de France, France