Longvida Curcumin Human Pharmacokinetics (PK) Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 9
- 试验地点
- 2
- 主要终点
- Changes in plasma curcumin metabolites among 3 different treatments
研究概览
简要总结
The primary objective of the study is to characterize the curcumin metabolites of 2 different capsule formulations of curcumin relative to unformulated Curcuma longa extract of Rhizomes including assessing relative bioavailability and absorption/kinetic profile of curcumonoids and their metabolites in human plasma and urine after acute consumption.
详细描述
This study is a randomized, 3-arm, double-blinded, within subject cross-over trial focused on understanding pharmacokinetic profile of curcuminoids and their metabolites after intake of curcumin supplement with different capsule formulations.
A planned sample size of 6 will be enrolled into the study. This study will require one initial screening visit and 3 weekly visits. This study will take approximately 4 weeks per subject to complete.
The initial screening visit will provide subject with the informed consent document and determine subject eligibility through anthropometric measurements, vital signs, fasting blood glucose test (finger prick), and completion of a survey relate to general eating, health, and exercise habits.
If willing and eligible to participate, subjects will be invited to participate in the study for 3 study days. Subjects will be instructed to maintain their usual diet pattern and physical activity throughout study duration.
Subject will arrive at the center in a fasted state for at least 10 hours, well hydrated and rested. Each study visit will require blood draws throughout the visit. After evaluation of subject's health status (via anthropometric, vital sign and blood glucose measurements and in-person interview), a Licensed health Care Professional will place a catheter in subject's arm for the purpose of multiple blood sample collections and take the initial blood draw in the fasting state. Subjects will be randomized to receive a curcumin supplement based on randomized treatment sequences for 3 study visits immediately after fasting blood draw. The sequences of receiving the supplement at each visit will be randomly assigned based on treatment sequences.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •• Men or women, 20-45 years of age with body mass index (BMI) in range from 18.5 to 24.9 kg/m2
- •Nonsmokers (Past smokers can be allowed if they have abstinence for minimum of 2 years)
- •No clinical evidence of cardiovascular, metabolic, respiratory, renal, gastrointestinal or hepatic disease that may interfere with study outcomes
- •Not taking any medications that would interfere with outcomes of the study, i.e. lipid lowering medications, gastrointestinal medications, antibiotics, anti-inflammatory drugs, dietary supplements including fiber supplements, prebiotics and probiotics, etc.
- •Able to provide informed consent
- •Able to comply and perform the procedures requested by the protocol (including dietary restrictions, consumption of study treatments, blood and urine sample collection procedures and study visit schedule)
- •Minimum weight of 45 kg
排除标准
- •Men and women who smoke
- •Men and women with known or suspected intolerance, allergies or hypersensitivity to study foods or treatments
- •Men and women known to have/diagnosed with diabetes mellitus
- •Men and women who have fasting blood glucose concentrations > 125 mg/dL
- •Men and women who have uncontrolled blood pressure >160 mmHg (systolic) or 100 mmHg (diastolic)
- •Men and women with documented vascular disease, e.g., heart failure, myocardial infarction, stroke, angina, related surgeries, etc. that, in the opinion of the investigator, could interfere with the interpretation of the study results
- •Men and women with cancer other than non-melanoma skin cancer in previous 5 years
- •Men and women diagnosed with chronic constipation, diarrhea or other chronic gastrointestinal complaint (e.g. irritable bowel syndrome)
- •Women who are known to be pregnant (pregnancy test will be completed for female subjects) or who are intending to become pregnant over the course of the study
- •Women who are lactating
- •Taking medication or dietary supplements that may interfere with the outcomes of the study; e.g., antioxidant supplement, anti-inflammation, lipid lowering medication, blood pressure lowering medication, etc... Subjects may choose to go off dietary supplements (requires 30 days washout); e.g., fish oil, probiotics, etc...
- •Men and women who has participated in prebiotics or laxative trial within 3 months prior to enrollment or any other clinical trial within 1 month
- •Men and women who have donated blood within 3 months of the Screening Visit and blood donors/participants for whom participation in this study will result in having donated more than 1500 milliliters of blood in the previous 12 months.
- •Men and women who are vegans
- •History of an eating disorder (e.g., anorexia nervosa, bulimia nervosa, or binge eating) diagnosed by a health professional
- •Substance (alcohol or drug) abuse within the last 2 years
- •Excessive coffee and tea consumers (> 5 cups/day)
- •Men and women who do excessive exercise regularly or athlete
- •Unstable weight: gained or lost weight +/- 5 kg (11 lbs) in previous 2 months
- •Women who are taking unstable dose and brand of hormonal contraceptives and/or stable dose and brand less than 6 months
- •Unusual working hours i.e., working overnight (e.g. 3rd shift)
结局指标
主要结局
Changes in plasma curcumin metabolites among 3 different treatments
时间窗: 8 hours Postprandial Study
Differences in plasma metabolites among 3 treatments
次要结局
- Changes in urine metabolites among 3 different treatments(8 hours Postprandial Study)