Effects of Occlusion Exercise on blood pressure in patients with Knee Arthrosis
- Conditions
- Knee osteoarthritis
- Registration Number
- RBR-7gvrmm
- Lead Sponsor
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- Not specified
Post-menopausal women between 40-85 years, with knee osteoarthritis according to the criteria proposed by the American College of Rheumatology. The participants should present grade II or III of severity of the osteoarthritis according to Kellgren & Lawrence and pain rated between 2 and 8 in the visual analogue scale.
The participants will be excluded if they present: cardiovascular, pulmonary, metabolic or any other disease that could preclude the procedures; systolic blood pressure greater than 160/105 mmHg; ischemia or arrhythmia during the exercise test; lower limb venous insufficiency; previous thrombosis and/or phlebitis in lower limbs; musculoskeletal impairment that preclude the performance of physical activity; body mass index greater than 35 kg/m2; under use of medications affecting the autonomic nervous system (e.g., beta blockers, and non-dihydropyridine calcium channel blocker); under use of anticoagulants; under glucocorticoid infiltration in the last 3 months; or under use of any glucorticoid in the last 3 months.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Beat-by-beat blood pressure using a photoplethysmographic monitor (Finometer, FMS, Inc., Amsterdam, Netherlands) connected to a finger cuff. This assessment will be performed before, during and after the exercise. ;Endothelial function using a vascular ultrasound and the flow-mediated dilation technique. This assessment will be performed before and after the exercise.
- Secondary Outcome Measures
Name Time Method