The Molecular Pathogenesis of Late-onset Fuchs' Endothelial Corneal Dystrophy
Completed
- Conditions
- Fuchs' Endothelial Dystrophy
- Interventions
- Other: No intervention
- Registration Number
- NCT01795001
- Lead Sponsor
- Universitaire Ziekenhuizen KU Leuven
- Brief Summary
The purpose of this study is to gain further insights into the molecular pathogenesis of Fuchs' endothelial corneal dystrophy (FECD), to identify targets for potential specific drug therapy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 460
Inclusion Criteria
- FECD
- normal corneas (including enucleations for uveal melanoma)
- non-FECD oedematous corneas
Exclusion Criteria
- prior irradiation therapy for uveal melanoma
- corneal extension of uveal melanoma
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description normal control No intervention tissue samples from patients with normal corneas non-FECD edematous control No intervention tissue samples from patients with corneal edema but without FECD late-onset FECD No intervention tissue samples from patients with late-onset Fuchs' endothelial corneal dystrophy (FECD)
- Primary Outcome Measures
Name Time Method cytokine levels at time of prelevation (once, no intervention) dosage of cytokine levels in aqueous humour (exploratory, non-interventional study)
gene expression levels at time of prelevation (once, no intervention) microarray expression analysis, reverse transcriptase - quantitative polymerase chain reaction (RT-qPCR), RNA-sequencing (exploratory, non-interventional study)
protein content at time of prelevation (once, no intervention) immunohistochemistry and immunofluorescence
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Translational Cell and Tissue Research - campus Sint-Raf - UZ Leuven
🇧🇪Leuven, Belgium