Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk in Adolescents at Clinical High Risk for Psychosis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 54
- 试验地点
- 2
- 主要终点
- Processing Speed domain score from the MATRICS Consensus Cognitive Battery (MCCB)
研究概览
简要总结
This 10 week intervention, Specific Cognitive Remediation with Surround (or SCORES), is designed to target processing speed, a cognitive domain related directly to social functioning, which in turn, represents a vulnerability factor for psychosis. This remotely-delivered intervention combining targeted cognitive training exercises and group support was developed to directly impact processing speed, and at the same time, boost motivation and engagement in adolescents at risk for schizophrenia and other psychotic disorders.
详细描述
This study evaluates the effectiveness of a cognitive remediation (CR) program plus group coaching and support designed to improve processing speed and, in turn, social functioning and attenuated positive symptoms in individual considered Clinical High Risk for psychosis. The SCORES (Specific COgnitive REmediation with Support) intervention is a novel Cognitive Remediation program combined with group coaching, performance-based rewards, game-like tasks, and educational elements to increase engagement and retention. The study is funded by a R61/R33 award. In the R61 phase, all participants were asked to complete 40 hours of Cognitive Remediation or brain training (4 hours per week/10 weeks) with a mid-point assessment (at 5 weeks) to determine the training dose needed to impact processing speed as measured by the Matrics Cognitive Consensus Battery. The current R33 (Phase 2) will look to replicate the results of the R61 and assess the specificity of the targeted intervention with the addition of a non-speeded cognitive training group..
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 14 Years 至 20 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Meet Clinical High Risk (CHR) criteria on the Structured Interview for Psychosis Risk Syndromes, defined by the presence of at least one attenuated positive symptom at a moderate to severe level
- •A score representing 0.5 SD below the mean on Animal Naming, Trails A or BACS: Symbol Coding from the MATRICS Consensus Cognitive Battery (MCCB).
排除标准
- •Any DSM 5 Schizophrenia-Spectrum diagnosis
- •Non-English speaking
- •Past or current history of a clinically significant central nervous system disorder (e.g., seizure disorder)
- •Estimated IQ<70
- •Significant head injury
- •Significant substance abuse
- •Significant visual or auditory impairment.
结局指标
主要结局
Processing Speed domain score from the MATRICS Consensus Cognitive Battery (MCCB)
时间窗: Baseline, Mid-Treatment (5 weeks), Post Treatment (10 weeks)
Change in processing speed domain score and individual measures within the domain.
次要结局
- Global Functioning: Social (GF:Social) scale (Phase 2/R33 only)(Baseline, Mid-Treatment (5 weeks), Post Treatment (10 weeks))
- SIPS/SOPS: Positive Symptoms (Phase 2/R33 only)(Baseline, Mid-Treatment (5 weeks), Post Treatment (10 weeks))