Is the Radiation Field, Dose and Fractionation Crucial for the Development of Mandibular Complications When Treating Malignancies in the Oropharyngeal Region?
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Complications related to dose, time and position of radiotherapy
研究概览
简要总结
Radiotherapy is inhibiting the healing capacity of the mandibular bone. Late complications as bone exposure, fracture of the jaw, osteoradionecrosis might be a consequence of this vulnerability. A factor that could be involved in the development of complications is field of radiation. There are limited number of studies investigating this relation.
Retrospective analysis of a head and neck oncology register with prospectively included patients will be performed. Patients will be related to the University hospitals in Lund, Umea, Orebro, Stockholm. A thorough analysis of the medical journals in this group of patients will be performed. Included patients have been treated with combination of surgery and radiotherapy to treat malignancies in the head and neck region. At least 12 months follow up period is needed for inclusion.
The scientific aim is to investigate weather the field of radiation and fractionation is crucial for developing the formentioned complications.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of the head and neck malignancy
- •Must have recieved radiotherapy as primary treatment alone or combination treatment together with surgery
- •Exclusion criteria
- •less than 12 months follow up
- •Under 18 years of age
排除标准
- 未提供
结局指标
主要结局
Complications related to dose, time and position of radiotherapy
时间窗: The measurements will be done from the end of radiotherapy and atleast 1 year postoperatively.
Complications as Osteoradionecrosis will be identified and compared with the dose of radiation, how long ago since the radiotherapy was given and where in the mouth the complication has developed.
次要结局
未报告次要终点