The Feasibility of a Prehabilitation Program in the Liver Transplant Population at Barnes-Jewish Hospital

Not Applicable

Completed

• Conditions: Physical Activity; End Stage Liver Disease
• Interventions: Procedure: Exercise

• Registration Number: NCT02444273
• Lead Sponsor: Washington University School of Medicine

Brief Summary

The primary outcome of this study is to demonstrate the feasibility of a prehabilitation program at Barnes Jewish Hospital for liver transplant candidates. Those patients who consent to participate in the study and are placed on the transplant list will be randomized into either the control or intervention group. The intervention group receives a personalized home exercise program along with weekly phone calls to provide coaching, mentoring and motivation. Data collected at baseline, post-transplant and, post-transplant follow up will be compared among the two study groups. The secondary outcomes include: normative data of functional measures for patients with end stage liver disease and to determine the effect size for future research on prehabilitation in the patient population.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-10
• Study First Submitted: 2015-04-07
• Study First Submitted QC: 2015-05-11
• Study First Posted: 2015-05-14
• Primary Completion: 2017-12
• Study Completion: 2017-12
• Status Verified: 2018-05
• Last Update Submitted: 2018-05-09
• Last Update Posted: 2018-05-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 101

Inclusion Criteria

• Being evaluated for liver transplantation by Barnes Jewish Hospital medical team

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Exclusion Criteria

• Non-english speaking
• Medical contraindications to exercise as determined by the medical team

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Exercise Group	Exercise	Subjects will receive a personalized home exercise program and regular phone calls from a therapist to monitor and promote activity.

Primary Outcome Measures

Name	Time	Method
Feasibility of a prehabilitation program.	2 Years	Feasibility will be measured by participation and outcome assessment measures.

Secondary Outcome Measures

Name	Time	Method
Normative data on 10 meter walk for patients with end stage liver disease.	Baseline
Normative data on Timed Up and Go for patients with end stage liver disease.	Baseline
Normative data on Modified Dynamic Gait Index for patients with end stage liver disease.	Baseline
Normative data on Five Time Sit to Stand for patients with end stage liver disease.	Baseline
Normative data on 6 Minute Walk Test for patients with end stage liver disease.	Baseline