The Effects of Perioperative Dexmedetomidine Administration on Immune Suppression and Outcomes in Patients With Uterine Cancer Undergoing Radical Resection

Not Applicable

Completed

• Conditions: Uterine Cancer
• Interventions: Drug: Dexmedetomidine group; Drug: Control group

• Registration Number: NCT02896413
• Lead Sponsor: Yonsei University

Brief Summary

Surgical stress and anesthesia may cause immunosuppression in immunocompromised cancer patients. The natural killer (NK) cell is a critical part of anti-tumor immunity. Dexmedetomidine has sympatholytic effect and preserves NK cell function. This study investigate the effect of dexmedetomidine on immune suppression and postoperative outcomes in patients undergoing uterine cancer resection.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-06-02
• Study First Submitted: 2016-09-06
• Study First Submitted QC: 2016-09-06
• Study First Posted: 2016-09-12
• Primary Completion: 2018-10-24
• Study Completion: 2018-10-24
• Status Verified: 2021-05
• Last Update Submitted: 2021-05-03
• Last Update Posted: 2021-05-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

• patient between 20 and 70 of age with ASA physical status Ⅰ-Ⅲ
• patient scheduled for uterine cancer surgery

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Exclusion Criteria

• ASA physical status Ⅳ
• severe hepatorenal disease
• infection
• metastasis to other organ
• problem with communication

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Dexmedetomidine Group	Dexmedetomidine group	dexmedetomidine infusion (0.4 mcg/kg/h) from immediately after anesthetic induction to 24 h after surgery
Control Group	Control group	0.9% saline infusion

Primary Outcome Measures

Name	Time	Method
natural killer cell cytotoxicity	postoperative day 5	Natural killer cell cytotoxicity is measured with NK Vue Kit™(ATGen, Gyeonggi-do, Korea).

Secondary Outcome Measures

Name	Time	Method
inflammatory response	postoperative day 5	inflammatory response is assessed by measuring levels of proinflammatory cytokines.

Trial Locations

Locations (1)

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine; 🇰🇷 Seoul, Korea, Republic of