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Clinical Trials/NCT05248295
NCT05248295
Completed
Not Applicable

Investigating the Effects of Rhythm and Entrainment on Fluency in People With Aphasia

MGH Institute of Health Professions1 site in 1 country100 target enrollmentDecember 4, 2018

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Aphasia
Sponsor
MGH Institute of Health Professions
Enrollment
100
Locations
1
Primary Endpoint
Percent Syllables Correct
Status
Completed
Last Updated
11 months ago

Overview

Brief Summary

Speaking in unison with another person is included as a part of many treatment approaches for aphasia. It is not well understood why and how this technique works. One goal of this study is to determine who benefits from speaking in unison, and what characteristics of speech are most helpful. Another goal is to investigate a possible mechanism for this benefit: why does speaking in unison help? A possible mechanism for this benefit is examined, by testing whether the degree of alignment of a person's speech with that of another speaker can account for unison benefit.

Detailed Description

Aphasia is an acquired language disorder, most commonly due to stroke. It can affect an individual's ability to speak, understand spoken language, read, and write. Many treatments designed to improve spoken language in persons with aphasia (PWAs) use unison speech, having the person with aphasia speak along with the clinician or with a recording. One goal of this study is to determine who benefits from speaking in unison, and what characteristics of speech help them the most. Another goal is to investigate a possible mechanism for this benefit: why does speaking in unison help? This knowledge is important because understanding who benefits from this commonly used and potentially powerful therapy component, under which conditions they benefit, and why they do, is critical for customizing therapy so it can be as effective and efficient as possible. Unison speech is conducted using one of two different timing patterns: (1) a natural conversational pattern, which is used in everyday conversations, or (2) a metrical pattern, which follows a beat-based timing framework, as in songs or some poems. In either case, precisely aligning one's speech with that of another person (i.e., entraining one's speech) requires prediction: each speaker must plan their own speech motor commands before having heard the other speaker say the words they are planning. Natural conversational timing requires the speaker to make use of knowledge about language, particularly grammar, to align with the other person. In contrast, a metrical pattern allows a speaker to predict speech timing without relying heavily on language-based knowledge. Given that many PWAs have impaired grammar, we hypothesize that most PWAs will benefit more from speaking in unison to sentences with metrical vs. conversational timing patterns. However, there is great variation in linguistic, motor speech, and timing skills across PWAs, so metrical and conversational timing patterns are likely to have different degrees of effectiveness for different individuals. Results from this study will demonstrate how individual characteristics and speech timing affect whether or not a person with aphasia benefits from speaking in unison. Results will also indicate whether a speaker's ability to predict speech timing is necessary for a benefit of unison speech. Prediction ability will be measured by how closely the speaker aligns their speech with a spoken model.

Registry
clinicaltrials.gov
Start Date
December 4, 2018
End Date
June 28, 2023
Last Updated
11 months ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
MGH Institute of Health Professions
Responsible Party
Principal Investigator
Principal Investigator

Lauryn Zipse, Ph.D., CCC-SLP

Associate Professor

MGH Institute of Health Professions

Eligibility Criteria

Inclusion Criteria

  • Native-speaker fluency in American English (prior to stroke for people with aphasia)
  • Controls must report no history of speech, language, neurological disorders, or stroke
  • People with aphasia must be at least 6-months post-stroke, and aphasia must be due to stroke

Exclusion Criteria

  • Inadequate hearing ability to reliably complete task: fail hearing screen
  • Inadequate cognitive ability to understand and remember task: fail cognition screening (different measures for controls and people with aphasia)
  • Inadequate speech repetition ability to complete task, or to be considered a control: fail speech repetition screening (different thresholds for controls and people with aphasia)
  • Inadequate auditory comprehension ability to understand task: fail auditory comprehension screen (people with aphasia only)

Outcomes

Primary Outcomes

Percent Syllables Correct

Time Frame: 1 day study visit

The percentage of syllables correctly repeated from the target sentences will be computed for each contrast, Unison vs. Solo and Metrical vs. Conversational, capturing all 4 conditions in the 2x2 design (Unison Metrical, Unison Conversational, Solo Metrical, Solo Conversational). A protocol will be used to score syllables for correctness.

Secondary Outcomes

  • Mean Syllable Offset From Model(1 day study visit)

Study Sites (1)

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