Corneal Cross Linking and Topography Guided Excimer Laser Treatment
Phase 3
Terminated
- Conditions
- KeratoconusPellucid Marginal Degeneration
- Registration Number
- NCT01682993
- Lead Sponsor
- Medical University of Vienna
- Brief Summary
Topography guided laser treatment enables the surgeon to correct higher order aberrations in corneas with irregular astigmatism. Several case reports and small uncontrolled trials have been published on the combination of this treatment with corneal cross linking (CCL) in patients with ectatic corneal diseases.
This randomized study will evaluate the safety and efficacy of a combined treatment of corneal cross linking with a partial topography guided excimer laser treatment in eyes with progressive ectatic corneal diseases.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- Signed informed consent
- Patient age 18 - 40 years
- Documented progressive corneal ectatic disease except post LASIK/LASEK ectasia
Exclusion Criteria
- Allergy to one of the used substances
- Tendency towards excessive scar formation
- Pregnancy
- Rheumatic diseases
- Central corneal thickness below 450 µm
- Active infection of the study eye
- Previous corneal surgery of the study eye
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Safety (Pachymetry, K-readings) 1 year uncorrected visual acuity (UVCA) 1 year best corrected visual acuity (BCVA) 1 year
- Secondary Outcome Measures
Name Time Method Progression of ectatic disease (by use of maximum keratometry readings = Kmax) 1 year
Trial Locations
- Locations (1)
Medical University of Vienna, Department of Ophthalmology
🇦🇹Vienna, Austria
Medical University of Vienna, Department of Ophthalmology🇦🇹Vienna, Austria