Effects of Walking Apnea at Low Lung Volume on Hypoalgesia, Cardiovascular Function and Respiratory Function
Trial Snapshot
- Phase
- Phase 3
- Status
- Recruiting
- Sponsor
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Pain pressure threshold (PPT) on thumb, anterior tibial and spinous process of C7
Study Overview
Brief Summary
The aim of this randomized controlled study is to explore the hypoalgesic response of a 6 minutes of intermittent walking apneas training session at low lung volume in healthy subjects; also, as secondary objectives, to analyze the cardiovascular and respiratory response produced during the intervention.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Double (Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Asymptomatic subjects aged between 18 and 64 years.
Exclusion Criteria
- •Cardiovascular, respiratory, metabolic, neurological or osteomuscular signs or pathologies.
- •History of epilepsy.
- •Pharmacological treatment.
- •Participants who present any type of pain on the day of the measurements or who have frequently suffered pain during the previous 4 weeks.
Outcomes
Primary Outcomes
Pain pressure threshold (PPT) on thumb, anterior tibial and spinous process of C7
Time Frame: before and after intervention (up 30 minutes)
PPT is tested on the dorsal base of the distal phalanx of the thumb on the dominant side and on the muscle belly of the tibialis anterior on the dominant side. The region to be pressed is marked with a pen. The patient is instructed to report with the first appearance of the sensation of "discomfort". An ascending ramp of 0.5 kg/cm/s is applied, at the rhythm of a metronome. The measurement is started on the thumb, and alternated with tibia and C7 until 3 measurements of each region are obtained, enough time to give 30 seconds of rest between measurements in the same region. This protocol has demonstrated high inter-observer reliability measuring healthy subjects (ICC = 0.91).
Secondary Outcomes
- Rate of perceived exertion (RPE)(immediately after intervention (up 10 seconds))
- Pittsburg Sleep Quality Index (PSQI)(before intervention (up 5 minutes))
- Oxygen saturation(during intervention (up 6 minutes))
- Perceived Stress Scale (PSS)(before intervention (up 5 minutes))
- Global Physical Activity Questionnaire (GPAQ)(before intervention (up 5 minutes))
- Blood pressure(before, during and after intervention (up 10 minutes))
- Heart rate(during intervention (up 6 minutes))
Investigators
Fran de Asís Fernández
Fran DeAsís-Fernández
Centro Universitario La Salle