MedPath

Levetiracetam 750 mg Tablets Under Fasting Conditions

Phase 1
Completed
Conditions
Healthy
Interventions
Registration Number
NCT00849862
Lead Sponsor
Teva Pharmaceuticals USA
Brief Summary

The objective of this study is to compare the rate and extent of absorption of a test formulation of Levetiracetam and the reference Keppra® administered as a 1 x 750 mg tablet under fasting conditions.

Detailed Description

Criteria for Evaluation: FDA Bioequivalence Criteria

Statistical Methods: FDA bioequivalence statistical methods

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
22
Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

Study Type
INTERVENTIONAL
Study Design
CROSSOVER
Arm && Interventions
GroupInterventionDescription
LevetiracetamLevetiracetamLevetiracetam 750 mg Tablet (test) dosed in first period followed by Keppra 750 mg Tablet (reference) dosed in second period
Keppra®Keppra®Keppra® 750 mg Tablet (reference) dosed in first period followed by Levetiracetam 750 mg Tablet (test) dosed in second period
Primary Outcome Measures
NameTimeMethod
Cmax - Maximum Observed ConcentrationBlood samples collected over 36 hour period

Bioequivalence based on Cmax

AUC0-inf - Area Under the Concentration-time Curve From Time Zero to Infinity (Extrapolated)Blood samples collected over 36 hour period

Bioequivalence based on AUC0-inf

AUC0-t - Area Under Concentration-time Curve From Time Zero to Time of Last Non-zero Concentration (Per Participant)Blood samples collected over 36 hour period

Bioequivalence based on AUC0-t

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

SFBC-Anapharm

🇨🇦

Sainte-Foy, Quebec, Canada

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