Einfluss Des Süßmodulierenden Polyphenols Hesperetin in Kombination Mit Saccharose Auf Die Blutglukose-Regulierung Und Energieaufnahme in Abhängigkeit Der Süßwahrnehmung Teil 2
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 39
- 试验地点
- 1
- 主要终点
- Change in blood glucose concentration
研究概览
简要总结
The aim of this cross-over intervention study is to investigate the influence of hesperetin applied in combination with sucrose in comparison to an equally sweet-tasting sucrose-only solution and an isocaloric sucrose-only solution on markers of energy metabolism
详细描述
The study is designed as a randomised cross-over intervention study with three arms. The aim is to investigate the influence of a 10% sucrose solution, corresponding to the sugar content of a conventional soft drink, compared to an equally sweet-tasting 7% sucrose solution in combination with 50 mg/L of the polyphenol hesperetin, and a less sweet 7% sucrose solution w/o hesperetin on time-dependent blood glucose fluctuations and ad libitum energy intake in metabolically healthy male volunteers.
To investigate the underlying mechanisms, the individual appetite score, metabolic and hormonal responses to the interventions and will be measured. In addition, the participants' individual thresholds for sweet taste, preference and consumption for sweet-tasting foods such as sugar and sweeteners, and their body composition will be recorded as potential influencing factors.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •non-smoking
- •normal taste responses towards sweet taste
排除标准
- •pregnancy or breast-feeding
- •regular smokers
- •disturbed glucose and/or lipid metabolism
- •regular intake of medication
- •known allergies against one of the test compounds
- •ageusia alcohol or drug addiction intake of antibiotics within the past 2 months
研究组 & 干预措施
10% Sucrose
10% (w/v) sucrose in water
干预措施: 10% Sucrose (Other)
Sucrose + Hesperetin
7% (w/v) sucrose in water + 50 mg/L Hesperetin
干预措施: Sucrose+ Hesperetin (Drug)
7% sucrose
7% (w/v) sucrose in water
干预措施: 7% Sucrose (Other)
结局指标
主要结局
Change in blood glucose concentration
时间窗: 15, 30, 60, 90, and 120 minutes after drinking the test solution
Change compared to baseline in blood glucose concentration \[mg/dL\] in plasma samples after drinking the test solution
Change in appetite score
时间窗: Difference between before and 120 minutes after drinking of the test solution
Change compared to baseline in the subjective rating of the individual feeling of hunger, fullness, as well as appetite for a snack or for something sweet on a unstructured, digital visual analog scale ranging from 0-10 cm in comparison to baseline
Change in food intake
时间窗: 120 minutes after drinking of the test solution
Ad libitum food intake from a standardized breakfast
次要结局
- Change in regulating hormones(15, 30, 60, 90, and 120 minutes after drinking the test solution)
研究者
Barbara Lieder
Professor and Vice Chair Department of Physiological Chemistry
University of Vienna