Fitness and Longevity in Exercise
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- HIV-1-infection
- Sponsor
- University of Maryland, Baltimore
- Enrollment
- 31
- Primary Endpoint
- Change from baseline Cardiorespiratory Fitness at 16 weeks
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
The study objective was to determine the safety and efficacy of aerobic exercise in older HIV-infected men in a randomized trial comparing different levels of exercise intensity.
Detailed Description
The study was a randomized trial of moderate-intensity versus high-intensity aerobic exercise (AEX) training in older HIV-infected adults. Funding was provided by K23 AG024896 (PI, Oursler) and the UMB Claude D. Pepper Older Americans Independence Center P60 AG12583 (PI, Goldberg). The central hypothesis was that high-intensity AEX training is well-tolerated and significantly increases aerobic capacity in older HIV-infected adults. The study met its objectives: 1. Scientific AIMS met: 1. High-intensity AEX training significantly increases aerobic capacity 2. Both moderate-intensity and high-intensity AEX training improve ambulatory function and endurance. 3. Activity of skeletal muscle oxidative enzymes is reduced, and associated with aerobic capacity. 2. Feasibility Objectives met: 1. AEX training is safe and well-tolerated in older HIV-infected adults. 2. Skeletal muscle punch biopsy is safe and well-tolerated in older HIV-infected adults. 3. Preliminary data was collected on plasma biomarkers of inflammation.
Investigators
KrisAnn Oursler
Physician
University of Maryland, Baltimore
Eligibility Criteria
Inclusion Criteria
- •stable combination antiretroviral therapy (cART)
Exclusion Criteria
- •AIDS defining conditions in the prior six months
- •Conditions that increase the risk of exercise training per the American College of Sports Medicine (ACSM)
Outcomes
Primary Outcomes
Change from baseline Cardiorespiratory Fitness at 16 weeks
Time Frame: 16-weeks
Cardiorespiratory Fitness measured by VO2peak
Secondary Outcomes
- Change from baseline body composition at 16 weeks(16-weeks)
- Change from baseline Six-minute walk distance at 16 weeks(16-weeks)
- Change from baseline exercise endurance at 16 weeks(16-weeks)