Fitness and Longevity in Exercise
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 31
- Primary Endpoint
- Change from baseline Cardiorespiratory Fitness at 16 weeks
Study Overview
Brief Summary
The study objective was to determine the safety and efficacy of aerobic exercise in older HIV-infected men in a randomized trial comparing different levels of exercise intensity.
Detailed Description
The study was a randomized trial of moderate-intensity versus high-intensity aerobic exercise (AEX) training in older HIV-infected adults. Funding was provided by K23 AG024896 (PI, Oursler) and the UMB Claude D. Pepper Older Americans Independence Center P60 AG12583 (PI, Goldberg).
The central hypothesis was that high-intensity AEX training is well-tolerated and significantly increases aerobic capacity in older HIV-infected adults.
The study met its objectives:
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Scientific AIMS met:
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High-intensity AEX training significantly increases aerobic capacity
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Both moderate-intensity and high-intensity AEX training improve ambulatory function and endurance.
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Activity of skeletal muscle oxidative enzymes is reduced, and associated with aerobic capacity.
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Feasibility Objectives met:
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Other
- Masking
- Double (Care Provider, Outcomes Assessor)
Eligibility Criteria
- Ages
- 50 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •stable combination antiretroviral therapy (cART)
Exclusion Criteria
- •AIDS defining conditions in the prior six months
- •Conditions that increase the risk of exercise training per the American College of Sports Medicine (ACSM)
Outcomes
Primary Outcomes
Change from baseline Cardiorespiratory Fitness at 16 weeks
Time Frame: 16-weeks
Cardiorespiratory Fitness measured by VO2peak
Secondary Outcomes
- Change from baseline body composition at 16 weeks(16-weeks)
- Change from baseline Six-minute walk distance at 16 weeks(16-weeks)
- Change from baseline exercise endurance at 16 weeks(16-weeks)
Investigators
KrisAnn Oursler
Physician
University of Maryland, Baltimore