NCT05009654已完成不适用
Carnitine Supplementation and Skeletal Muscle Function in Aging
Gdansk University of Physical Education and Sport0 个研究点目标入组 16 人开始时间: 2016年10月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 16
- 主要终点
- Muscle Carnitine Concentration using UPLC-MS/MS
研究概览
简要总结
The primary aim of the current research project is to explore whether leucine stimulates carnitine transport, and thus affecting muscle carnitine content.
A secondary aim of this project is to investigate the effect of carnitine with leucine supplementation on muscle strength and body composition.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 29 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •must be able to swallow tablets
排除标准
- •cardiovascular disease
- •liver disease
- •kidney disease
- •neuromuscular disease
- •gastrointestinal disorders (including stomach ulcers and erosions)
- •other severe chronic diseases
结局指标
主要结局
Muscle Carnitine Concentration using UPLC-MS/MS
时间窗: 24 weeks
vastus lateralis muscle biopsy taken before and after the supplementation procedure (\~20 cm proximal to the knee joint using a thin biopsy needle); carnitine concentration determined using ultra performance liquid chromatography - tandem mass spectrometer (UPLC-MS/MS) method
次要结局
- Muscle Strength using Biodex System 4 Pro dynamometer(24 weeks)
- Body Composition: Body Fat Mass, Fat Free Mass, and Skeletal Muscle Mass using a bioelectrical impedance analyzer (InBody720).(24 weeks)
研究者
Robert Olek
Principal Investigator
Gdansk University of Physical Education and Sport
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