Biological Markers Predicting Exercise Capacity in CF-LVAD Patients.

Completed

• Conditions: Heart Failure

• Registration Number: NCT02303236
• Lead Sponsor: Rigshospitalet, Denmark

Brief Summary

Establishing the association between biological markers and exercise capacity in continuous-flow left ventricular assist device patients.

Detailed Description

The aim of this study is to investigate if specific biological markers can predict exercise capacity in advanced heart failure patients supported with continuous-flow left ventricular assist device patients.

Study Timeline

• Study Start: 2014-11
• Study First Submitted: 2014-11-20
• Study First Submitted QC: 2014-11-24
• Study First Posted: 2014-11-27
• Primary Completion: 2016-12
• Study Completion: 2016-12-24
• Status Verified: 2017-10
• Last Update Submitted: 2017-10-03
• Last Update Posted: 2017-10-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• Stable CF-LVAD patients.

Exclusion Criteria

• Unstable CF-LVAD patients.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Biological markers	Blood sampling on study day and samples are subsequently stored frozen.	Analysis of blood will be carried out on all samples simultaneously, expected markers are pro-BNP, MRproANP, copeptin, Gal-3 and proADM.

Secondary Outcome Measures

Name	Time	Method
Exercise capacity	Examination on study day. Patients will only be followed on the day of the study. Exercise testing is performed as the last intervention on the study day.	Exercise capacity will be estimated by peak VO2 measurements on a upright ergometer bike with breath-by-breath gas analysis.

Trial Locations

Locations (1)

University Hospital Rigshospitalet.; 🇩🇰 Copenhagen, Kbh Oe, Denmark