Antimicrobial Susceptibility Testing Guided Triple Therapy in Salvage Helicobacter Pylori Treatment
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 120
- 主要终点
- Eradication rate of AST guided triple therapy
研究概览
简要总结
Helicobacter pylori (H. pylori), which infects about 50% of the global population, has been recognized as a main risk factor of multiple gastric pathologies, especially non-cardiac gastric cancer. Strongly evidence supports that H. pylori eradication is an effective approach to reduce the incidence of those pathologies.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Consecutive patients who are 18-70 years old with persistent H. pylori infection after first or second line treatment attempts.
排除标准
- •Enable to undergo upper endoscopy;
- •Patients with gastrectomy, acute GI bleeding and advanced gastric cancer;
- •Known or suspected allergy to study medications;
- •Taking bismuth and antibiotics in the previous four weeks, or taking proton pump inhibitor and H2-receptor blockers in the previous two weeks;
- •Currently pregnant or lactating
- •Inability to provide informed consent and other situations that could interfere with the examination or therapeutic protocol.
研究组 & 干预措施
clarithromycin susceptible
Patients will receive a 14-day triple therapy to eradicate H. pylori. The regimen is consist of Ilaprazole, amoxicillin and clarithromycin.
Ilaprazole 5 mg b.i.d is used as the proton pump inhibitor (PPI).
干预措施: amoxicillin (Drug)
clarithromycin susceptible
Patients will receive a 14-day triple therapy to eradicate H. pylori. The regimen is consist of Ilaprazole, amoxicillin and clarithromycin.
Ilaprazole 5 mg b.i.d is used as the proton pump inhibitor (PPI).
干预措施: clarithromycin (Drug)
clarithromycin susceptible
Patients will receive a 14-day triple therapy to eradicate H. pylori. The regimen is consist of Ilaprazole, amoxicillin and clarithromycin.
Ilaprazole 5 mg b.i.d is used as the proton pump inhibitor (PPI).
干预措施: Ilaprazole (Drug)
metronidazole susceptible
Patients will receive a 14-day triple therapy to eradicate H. pylori. The regimen is consist of Ilaprazole, amoxicillin and tinidazole.
干预措施: amoxicillin (Drug)
metronidazole susceptible
Patients will receive a 14-day triple therapy to eradicate H. pylori. The regimen is consist of Ilaprazole, amoxicillin and tinidazole.
干预措施: tinidazole (Drug)
metronidazole susceptible
Patients will receive a 14-day triple therapy to eradicate H. pylori. The regimen is consist of Ilaprazole, amoxicillin and tinidazole.
干预措施: Ilaprazole (Drug)
levofloxacin susceptible
Patients will receive a 14-day triple therapy to eradicate H. pylori. The regimen is consist of Ilaprazole, amoxicillin and levofloxacin.
干预措施: amoxicillin (Drug)
levofloxacin susceptible
Patients will receive a 14-day triple therapy to eradicate H. pylori. The regimen is consist of Ilaprazole, amoxicillin and levofloxacin.
干预措施: levofloxacin (Drug)
levofloxacin susceptible
Patients will receive a 14-day triple therapy to eradicate H. pylori. The regimen is consist of Ilaprazole, amoxicillin and levofloxacin.
干预措施: Ilaprazole (Drug)
furazolidone susceptible
Patients will receive a 14-day triple therapy to eradicate H. pylori. The regimen is consist of Ilaprazole, amoxicillin and furazolidone.
干预措施: amoxicillin (Drug)
furazolidone susceptible
Patients will receive a 14-day triple therapy to eradicate H. pylori. The regimen is consist of Ilaprazole, amoxicillin and furazolidone.
干预措施: furazolidone (Drug)
furazolidone susceptible
Patients will receive a 14-day triple therapy to eradicate H. pylori. The regimen is consist of Ilaprazole, amoxicillin and furazolidone.
干预措施: Ilaprazole (Drug)
tetracycline susceptible
Patients will receive a 14-day triple therapy to eradicate H. pylori. The regimen is consist of Ilaprazole, amoxicillin and tetracycline.
干预措施: amoxicillin (Drug)
tetracycline susceptible
Patients will receive a 14-day triple therapy to eradicate H. pylori. The regimen is consist of Ilaprazole, amoxicillin and tetracycline.
干预措施: tetracycline (Drug)
tetracycline susceptible
Patients will receive a 14-day triple therapy to eradicate H. pylori. The regimen is consist of Ilaprazole, amoxicillin and tetracycline.
干预措施: Ilaprazole (Drug)
结局指标
主要结局
Eradication rate of AST guided triple therapy
时间窗: 3 months
次要结局
- the rate of good compliance (take pills more than 90%)(3 months)
- the rate of adverse events happening(3 months)
- the rate of improving dyspepsia symptoms after H. pylori eradication(3 months)
研究者
Yanqing Li
Vice president of Qilu Hospital
Shandong University