Subcapsular Orchiectomy in Men With Klinefelter Syndrome

Not Applicable

Completed

• Conditions: Klinefelter Syndrome
• Interventions: Procedure: Orchiectomy

• Registration Number: NCT01750632
• Lead Sponsor: Odense University Hospital

Brief Summary

Men with Klinefelter syndrome undergo unilateral subcapsular ochiectomy, and the removed testicular tissue is examined for presence of sperm and cryopreserved in small pieces for fertility treatment and scientific purposes. Prior to operation blood samples are frozen in a biobank.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-08
• Study First Submitted: 2012-12-08
• Study First Submitted QC: 2012-12-13
• Study First Posted: 2012-12-17
• Primary Completion: 2014-02
• Study Completion: 2014-12
• Status Verified: 2016-10
• Last Update Submitted: 2016-10-03
• Last Update Posted: 2016-10-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 14

Inclusion Criteria

• Klinefelter
• 15-40 years of age

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Exclusion Criteria

• inability to understand the study

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Orchiectomy	Orchiectomy	The patients undergo subcapsular orchiectomy

Primary Outcome Measures

Name	Time	Method
Presence of testicular sperm	Between 1 and 6 months

Secondary Outcome Measures

Name	Time	Method
Clinical pregnancy rate after ICSI with retrieved testicular sperm	participants will be followed for the duration of fertility treatment, an expected average of 6 months

Trial Locations

Locations (1)

Fertility Clinic, Odense University Hospital; 🇩🇰 Odense, Denmark