Evaluation of a novel test to detect subtle cognitive deficits in relapsing-remitting Multiple Sclerosis

Recruiting

• Conditions: G35; Multiple sclerosis

• Registration Number: DRKS00016600
• Lead Sponsor: Medizinische Fakultät Carl Gustav Carus

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-02-12
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 210

Inclusion Criteria

1. CIS or newly diagnosed MS patients (McDonald criteria). Diagnosis < 4 months
2. stable RRMS patients. Diagnosis < 48 months, stable immunomodulatory therapy > 6 months, no relapses within 6 months.
3. SPMS patients. Start of treatment < 20 years, EDSS < 6.5 and no relapses within 6 months.

Age between 18 and 50 years

Exclusion Criteria

Other neurological pre-existing conditions other than MS
- Psychiatric disorders
- Occurrence of learning disorders, severe head injuries, substance abuse, epilepsy
- Corticosteroid intake within 4 weeks before study participation
- Non-correctable hearing and visual impairments

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Reaction times (RTs) and error rates in the action cascading paradigm. EEG measures derived from EEG recordings during the administration of the action cascading paradigm.

Secondary Outcome Measures

Name	Time	Method
Integration of the EEG and behavioral data with the MRI data.