A randomized controlled clinical study on the treatment of mild to moderate knee osteoarthritis with traditional Chinese medicine ointment rubbing

Phase 1

• Conditions: knee osteoarthritis

• Registration Number: ITMCTR2022000081
• Lead Sponsor: Wuzhai County Hospital of traditional Chinese medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

(1) Meet the diagnostic criteria (refer to the diagnostic criteria of the guidelines for the diagnosis and treatment of osteoarthritis (2018 Edition) issued by the branch of orthopaedics of the Chinese Medical Association). ? Repeated knee pain in the past month; ? X-ray films (standing position or weight-bearing position) showed narrowing of joint space, subchondral bone sclerosis and / or cystic change, and osteophyte formation at the joint edge; ? Age = 50 years old; ? Morning stiffness time = 30min; ? There is bone fricative sound (sensation) during activity. It can be diagnosed if any 2 of ? and ? ? ? ? are met.); (2) Age 30 and above; (3) Western Ontario and McMaster University Osteoarthritis Index (WOMAC) = 48 points; (4) Kellgren Lawrence (K-L) is classified as grade I, II or III; (5) Fluent in speech, clear in mind, can accurately evaluate and describe their own discomfort symptoms; (6) Sign informed consent.

Exclusion Criteria

(1) The patient had a history of knee replacement; (2) The patient had a history of rheumatoid arthritis and bone tumor; (3) The patient has ligament injury or rupture; (4) Previous allergic history of Chinese herbal medicine (5) anti inflammatory and analgesic drugs were used within 1 week before enrollment; (6) The local knee joint was treated with topical drugs within 1 week before enrollment (7) the knee joint was treated with drug injection within 1 month before enrollment.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Visual analog scale;

Secondary Outcome Measures

Name	Time	Method
Knee injury and osteoarthritis outcome score;Thigh circumference;Western Ontario and McMaster Universities Osteoarthritis Index;