Guidance of Ultrasound in Intensive Care to Direct Euvolemia
- Conditions
- Acute Kidney Injury
- Interventions
- Diagnostic Test: Serial ultrasound assessments for GDTDiagnostic Test: Usual care
- Registration Number
- NCT03938038
- Brief Summary
The purpose of this study is to assess the effectiveness of routine ultrasound assessments of volume status and fluid responsiveness for goal-directed therapy (GDT)-based fluid resuscitation in reducing acute kidney injury (AKI) incidence and duration in trauma patients in a teaching institution.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 415
- Injured patients that are admitted to the trauma ICU
- Incarceration
- Pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Serial ultrasound assessments for GDT, then Usual Care Serial ultrasound assessments for GDT - Serial ultrasound assessments for GDT, then Usual Care Usual care - Usual care, then Serial ultrasound assessments for GDT Usual care - Usual care, then Serial ultrasound assessments for GDT Serial ultrasound assessments for GDT -
- Primary Outcome Measures
Name Time Method Number of Participants Who Receive 3 or More Ultrasound Volume Assessments within 24 hours of ICU admission Number of Acute Kidney Injury (AKI)-Free Days within 7 days of injury AKI will be defined by the Kidney Disease Improving Global Outcomes (KDIGO) criteria, and all stages will be considered AKI:
Stage 1 - Serum Creatinine 1.5-1.9 times baseline or ≥0.3 mg/dL increase Stage 2 - Serum Creatinine 2-2.9 times baseline Stage 3 - Serum Creatinine 3 times baseline or Increase in serum creatinine to ≥4 mg/dL or Initiation of renal replacement therapy
- Secondary Outcome Measures
Name Time Method Type of Fluids Administered 48 hours Number of Participants With Acute Kidney Injury (AKI) within the first 7 days of ICU admission AKI will be defined by the Kidney Disease Improving Global Outcomes (KDIGO) criteria, and all stages will be considered AKI:
Stage 1 - Serum Creatinine 1.5-1.9 times baseline or ≥0.3 mg/dL increase Stage 2 - Serum Creatinine 2-2.9 times baseline Stage 3 - Serum Creatinine 3 times baseline or Increase in serum creatinine to ≥4 mg/dL or Initiation of renal replacement therapyQuantity of Fluids Administered 48 hours Quantity of Diuretics Administered 48 hours Time to Lactate Normalization within the first 7 days of ICU admission Time to Creatinine Concentration <1.5 mg/dL or to Prehospital Baseline within the first 7 days of ICU admission Number of Participants With Need for Renal Replacement Therapy within the first 30 days of ICU admission Number of ICU-free Days within first 30 days after injury Stage of Acute Kidney Injury (AKI) within the first 7 days of ICU admission AKI will be defined by the Kidney Disease Improving Global Outcomes (KDIGO) criteria, and all stages will be considered AKI:
Stage 1 - Serum Creatinine 1.5-1.9 times baseline or ≥0.3 mg/dL increase Stage 2 - Serum Creatinine 2-2.9 times baseline Stage 3 - Serum Creatinine 3 times baseline or Increase in serum creatinine to ≥4 mg/dL or Initiation of renal replacement therapyNumber of Ventilator-free Days within first 30 days after injury Time to Base Excess Normalization within the first 7 days of ICU admission
Trial Locations
- Locations (1)
The University of Texas Health Science Center at Houston
🇺🇸Houston, Texas, United States