Autoimmune Hepatitis Study

Terminated

• Conditions: Hepatitis, Autoimmune

• Registration Number: NCT00286663
• Lead Sponsor: University of Rochester

Brief Summary

The purpose of the study is to determine the role special antibodies play in possibly identifying Autoimmune Hepatitis through the following:

Identify the response of specific T cells to antibodies and Monitor the response of the cells that regulate the immune system

Detailed Description

The object of this protocol is to characterize and monitor auto antigen-specific T cell responses in blood and liver biopsies of patients with anti-SLA/LP or anti-LKM-positive autoimmune hepatitis. The results will provide insight into the pathogenesis of autoimmune hepatitis and the monitoring of auto antigen-specific T cell reactivity in correlation to disease exacerbation and therapy.

Study Timeline

• Study Start: 2006-01
• Study First Submitted: 2006-02-01
• Study First Submitted QC: 2006-02-01
• Study First Posted: 2006-02-03
• Study Completion: 2008-06
• Status Verified: 2008-07
• Last Update Submitted: 2008-07-08
• Last Update Posted: 2008-07-09

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Male or female subjects,All ethnic groups, Over 18 years of age, anti-SLA/LP or anti-LKM-positive autoimmune hepatitis

Exclusion Criteria

Subjects with a hematocrit of <25

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified