NCT00286663
Terminated
Not Applicable
Evaluation of the Cellular Immune Response in Patients With Anti-SLA/LP- or Anti-LKM-Positive Autoimmune Hepatitis
ConditionsHepatitis, Autoimmune
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hepatitis, Autoimmune
- Sponsor
- University of Rochester
- Enrollment
- 100
- Status
- Terminated
- Last Updated
- 17 years ago
Overview
Brief Summary
The purpose of the study is to determine the role special antibodies play in possibly identifying Autoimmune Hepatitis through the following:
Identify the response of specific T cells to antibodies and Monitor the response of the cells that regulate the immune system
Detailed Description
The object of this protocol is to characterize and monitor auto antigen-specific T cell responses in blood and liver biopsies of patients with anti-SLA/LP or anti-LKM-positive autoimmune hepatitis. The results will provide insight into the pathogenesis of autoimmune hepatitis and the monitoring of auto antigen-specific T cell reactivity in correlation to disease exacerbation and therapy.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Male or female subjects,All ethnic groups, Over 18 years of age, anti-SLA/LP or anti-LKM-positive autoimmune hepatitis
Exclusion Criteria
- •Subjects with a hematocrit of \<25
Outcomes
Primary Outcomes
Not specified
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