Genetics and genomics of hypertension associated with microinflammation, oxidative stress, chronic renal disease and heart failure.
- Conditions
- essential hypertensionhigh blood pressure100192801002914910057166
- Registration Number
- NL-OMON33614
- Lead Sponsor
- Interne Geneeskunde
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 200
- Men or women between 18 and 60 years of age at time of enrolment
- Essential hypertension diagnosed before the age of 50 years.
- At least 3 first-degree relatives of whom at least 1 should have hypertension and at least one from a different generation, willing to participate in the study.
- Written informed consent
- Any known form of secondary hypertension,
- Any known previous clinical complications of hypertension (angina, myocardial infarction, stroke, TIA, peripheral artery disease) at any time
- known renal disease, including GFR < 60 mL/min/1.73 m2 as estimated by the abbreviated MDRD formula, or kidney stones
- Kidney or other organ transplantation
- Type 1 diabetes mellitus
- Heart failure stage D (AHA/ACC criteria)
- Any malignant concomitant diseases or history of malignant diseases within the last five years, with exception of treated squamous skin cancer or basalioma
- Clinical or laboratory signs of acute infection.
- Systemic inflammatory diseases,
- Steroids or any other immunosuppressive drug
- Severe known liver disease (ALT or gamma-GT above three-fold of upper normal limit)
- Current alcohol consume of more than 21 drinks/week or drug abuse
- Pregnancy
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>To analyse genetic and genomic factors involved in the pathogenesis of<br /><br>hypertension.<br /><br>To analyse genetic, genomic and proteomic factors involved in changes in<br /><br>microalbuminuria.<br /><br>To analyse genetic, genomic and proteomic factors involved in changes in<br /><br>cardiac and large artery structure and function. </p><br>
- Secondary Outcome Measures
Name Time Method <p>To analyse the proteomic factors involves in the pathogenesis of hypertension.<br /><br>To explore the role of oxidative stress and microinflammation in the<br /><br>pathogenesis of hypertension.<br /><br>To analyse genetic, genomic and proteomic factors associated with renal<br /><br>phenotypes in hypertensive subjects: elevated urinary albumin excretion<br /><br>(microalbuminuria, proteinuria) salt-sensitivity, reduced GFR, and end-stage<br /><br>renal disease.<br /><br>To analyse genetic, genomic and proteomic factors associated with presence or<br /><br>development of heart dysfunction and failure in hypertensive patients. </p><br>