Genetics and genomics of hypertension associated with microinflammation, oxidative stress, chronic renal disease and heart failure. - InGenious HyperCare

Interne Geneeskunde0 个研究点目标入组 200 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•- Men or women between 18 and 60 years of age at time of enrolment
•- Essential hypertension diagnosed before the age of 50 years.
•- At least 3 first-degree relatives of whom at least 1 should have hypertension and at least one from a different generation, willing to participate in the study.
•- Written informed consent

•- Any known form of secondary hypertension,
•- Any known previous clinical complications of hypertension (angina, myocardial infarction, stroke, TIA, peripheral artery disease) at any time
•- known renal disease, including GFR < 60 mL/min/1.73 m2 as estimated by the abbreviated MDRD formula, or kidney stones
•- Kidney or other organ transplantation
•- Type 1 diabetes mellitus
•- Heart failure stage D (AHA/ACC criteria)
•- Any malignant concomitant diseases or history of malignant diseases within the last five years, with exception of treated squamous skin cancer or basalioma
•- Clinical or laboratory signs of acute infection.
•- Systemic inflammatory diseases,
•- Steroids or any other immunosuppressive drug
•- Severe known liver disease (ALT or gamma-GT above three-fold of upper normal limit)
•- Current alcohol consume of more than 21 drinks/week or drug abuse
•- Pregnancy

发起方

Interne Geneeskunde