NL-OMON33614
Completed
Not Applicable
Genetics and genomics of hypertension associated with microinflammation, oxidative stress, chronic renal disease and heart failure. - InGenious HyperCare
Interne Geneeskunde0 sites200 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- essential hypertension
- Sponsor
- Interne Geneeskunde
- Enrollment
- 200
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\- Men or women between 18 and 60 years of age at time of enrolment
- •\- Essential hypertension diagnosed before the age of 50 years.
- •\- At least 3 first\-degree relatives of whom at least 1 should have hypertension and at least one from a different generation, willing to participate in the study.
- •\- Written informed consent
Exclusion Criteria
- •\- Any known form of secondary hypertension,
- •\- Any known previous clinical complications of hypertension (angina, myocardial infarction, stroke, TIA, peripheral artery disease) at any time
- •\- known renal disease, including GFR \< 60 mL/min/1\.73 m2 as estimated by the abbreviated MDRD formula, or kidney stones
- •\- Kidney or other organ transplantation
- •\- Type 1 diabetes mellitus
- •\- Heart failure stage D (AHA/ACC criteria)
- •\- Any malignant concomitant diseases or history of malignant diseases within the last five years, with exception of treated squamous skin cancer or basalioma
- •\- Clinical or laboratory signs of acute infection.
- •\- Systemic inflammatory diseases,
- •\- Steroids or any other immunosuppressive drug
Outcomes
Primary Outcomes
Not specified
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