The association of paternal factors with recurrent pregnancy loss; REMI III study
Recruiting
- Conditions
- habitual abortionRecurrent miscarriages10010273
- Registration Number
- NL-OMON49845
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 270
Inclusion Criteria
Couples with unexplained recurrent pregnancy loss (defined according to the
ESHRE 2017 guideline) who visit the recurrent pregnancy loss clinic in the
Leiden University Medical Center (LUMC) or Erasmus Medical Center (EMC) are
included.
Exclusion Criteria
Exclusion criteria are
1. Known causes for RPL(parental chromosomal abnormalities, uterine anomalies,
acquired thrombophilia, thyroid autoimmunity)
2. Mentally or legally incapability
3. Pregnancy after oocyte- embryo or spermatozoa donation
4. Loss of < 2 pregnancies in current relationship
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Primary exposure of case control study: paternal age<br /><br><br /><br>Primary outcome of cohort study: the development of live birth within 5 years<br /><br>after initial visit of the recurrent miscarriage clinic</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary exposures of case control study: BMI, smoking, physical exercise,<br /><br>sperma apoptose, immunomodulatory factors in peripheral blood and seminal<br /><br>plasma (cytokines)<br /><br><br /><br>Secondary outcomes of cohort study: development of ongoing pregnancy (>24<br /><br>weeks), time interval until next pregnancy, development of pregnancy<br /><br>complications such as growth restriction, pre term delivery and pre eclampsia</p><br>