Preoperative ketamine nebulization on attenuation of incidence and severity of post-operative sore throat, hoarseness of voice and cough

Not yet recruiting

• Conditions: Diseases of the respiratory system,

• Registration Number: CTRI/2020/08/027485
• Lead Sponsor: JLN Medical College Ajmer

Brief Summary

The aim of this study is to evaluate the role of nebulization with ketamine in attenuating the incidence and severity of Post-operative sore throat, hoarseness of voice and cough in patients undergoing various surgeries under general anaesthesia with endotracheal intubation.

**PRIMARY OBJECTIVES**

To assess incidence and severity of

Post-operative sore throat (POST)

Post-operative Hoarseness of voice

Post-operative Cough

 **SECONDARY OBJECTIVES**

Haemodynamic changes (HR, SBP, DBP, MAP &SpO2)

Side effects, if any

Detailed Description

Not available

Study Timeline

• Study Start: 2020-01-09
• Last Update Posted: 2020-08-28

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Patients between 20-60 years of either sex Undergoing surgeries under general anaesthesia in supine position Duration of surgery up to 2 hours ASA physical status – I & II.

Exclusion Criteria

• Age < 20 and >60 years ASA physical status III & above Mallampatti grade >2 Any psychiatric disorder and history of epilepsy Neurosurgical patients with raised intracranial pressure Patients with known coronary artery disease, old myocardial infarction and ischemic heart disease Pregnancy Patient sensitive or allergic to study drug History of pre-operative sore throat, oral surgeries, asthma, chronic obstructive pulmonary disease, head and neck surgeries.
• Recent non-steroidal drug medication Anticipated difficult intubation Patient and/or his/her legally acceptable representative not willing to provide their voluntary written informed consent for participation in the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess incidence and severity of	Duration of study is around 1 yer
Post-operative sore throat (POST)	Duration of study is around 1 yer
Post-operative Hoarseness of voice	Duration of study is around 1 yer
Post-operative Cough	Duration of study is around 1 yer

Secondary Outcome Measures

Name	Time	Method
To assess	Haemodynamic changes (HR, SBP, DBP, MAP &SpO2)

Trial Locations

Locations (1)

JLN Medical College; 🇮🇳 Ajmer, RAJASTHAN, India

JLN Medical College

🇮🇳Ajmer, RAJASTHAN, India

Dr Naveen Kumar Jangid

Principal investigator

7014510966

njangid83@gmail.com