Effect of Preoperative ketamine nebulization on attenuation of incidence and severity of post-operative sore throat, hoarseness of voice and cough A randomized double blind study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- To assess incidence and severity of
研究概览
简要总结
The aim of this study is to evaluate the role of nebulization with ketamine in attenuating the incidence and severity of Post-operative sore throat, hoarseness of voice and cough in patients undergoing various surgeries under general anaesthesia with endotracheal intubation.
PRIMARY OBJECTIVES
To assess incidence and severity of
Post-operative sore throat (POST)
Post-operative Hoarseness of voice
Post-operative Cough
SECONDARY OBJECTIVES
Haemodynamic changes (HR, SBP, DBP, MAP &SpO2)
Side effects, if any
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 20.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients between 20-60 years of either sex Undergoing surgeries under general anaesthesia in supine position Duration of surgery up to 2 hours ASA physical status – I & II.
排除标准
- •Age < 20 and >60 years ASA physical status III & above Mallampatti grade >2 Any psychiatric disorder and history of epilepsy Neurosurgical patients with raised intracranial pressure Patients with known coronary artery disease, old myocardial infarction and ischemic heart disease Pregnancy Patient sensitive or allergic to study drug History of pre-operative sore throat, oral surgeries, asthma, chronic obstructive pulmonary disease, head and neck surgeries.
- •Recent non-steroidal drug medication Anticipated difficult intubation Patient and/or his/her legally acceptable representative not willing to provide their voluntary written informed consent for participation in the study.
结局指标
主要结局
To assess incidence and severity of
时间窗: Duration of study is around 1 yer
Post-operative sore throat (POST)
时间窗: Duration of study is around 1 yer
Post-operative Hoarseness of voice
时间窗: Duration of study is around 1 yer
Post-operative Cough
时间窗: Duration of study is around 1 yer
次要结局
- To assess(Haemodynamic changes (HR, SBP, DBP, MAP &SpO2))