COVID-19 Risk Stratification
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Coronavirus
- Sponsor
- Brigham and Women's Hospital
- Enrollment
- 1326
- Locations
- 1
- Primary Endpoint
- Suitable for discharge
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
The investigators seek to derive and validate a clinically useful risk score for patients with Coronavirus Disease 2019 to aide clinicians in the safe discharge of patients.
Detailed Description
The investigators a-priori plan the following analysis: 1. Derivation and Retrospective Validation. * Select all adult patients with a positive reverse transcription polymerase chain reaction for severe acute respiratory syndrome coronavirus 2 beginning March 1, 2020 until approximately 1000 patients are included. * Use 75% of this cohort to develop a simple risk-score that prognosticates a patient's suitability for discharge (no supplemental oxygen, no intensive care unit, and no death). Use multivariable logistic regression with forward selection informed by clinical judgement to choose variables a priori that emphasizes readily available data and easy calculation for use at the point of care. * Use 25% of this cohort to retrospectively validate the risk-score. 2. Prospective Validation. * Select all adult patients with a positive reverse transcription polymerase chain reaction for severe acute respiratory syndrome coronavirus 2 as soon as the derivation cohort in step 1 is assembled. Include approximately 250 patients. * Use this sample to prospectively validate the risk-score developed in part 1.
Investigators
David Levine
Associate Physician
Brigham and Women's Hospital
Eligibility Criteria
Inclusion Criteria
- •Positive reverse transcription polymerase chain reaction for severe acute respiratory syndrome coronavirus 2
- •Age 18 and older
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Suitable for discharge
Time Frame: Duration of participation in cohort, expected to be between 1 day and 20 days.
Patient with COVID-19 who does not require supplemental oxygen, does not require intensive care unit-level care, and does not die.