Correlation Between Melatonin Levels in Different Biological Fluids
Recruiting
- Conditions
- Neurodegenerative Diseases
- Interventions
- Other: blood and saliva sample and lumbar puncture diagnostic for specific neurological diseases
- Registration Number
- NCT05784090
- Lead Sponsor
- Istituto Auxologico Italiano
- Brief Summary
The goal of this observational study is to evaluate and to correlate melatonin levels in plasma, saliva and cerebrospinal fluid (CSF) samples of patients undergoing lumbar puncture diagnostic for specific neurological diseases.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 36
Inclusion Criteria
- Neurodegenerative disease
Exclusion Criteria
- Age < 18 years
- Pregnancy
- Coagulations disorders
- Anticoagulant therapy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description CT blood and saliva sample and lumbar puncture diagnostic for specific neurological diseases Controls AD blood and saliva sample and lumbar puncture diagnostic for specific neurological diseases Alzheimer's Disease NON AD blood and saliva sample and lumbar puncture diagnostic for specific neurological diseases Non Alzheimer's Disease
- Primary Outcome Measures
Name Time Method Melatonin levels in cerebrospinal fluid Baseline Analysis of melatonin levels by ELISA kit. Values expressed in pg/ml
Melatonin levels in plasma Baseline Analysis of melatonin levels by ELISA kit. Values expressed in pg/ml
Melatonin levels in saliva Baseline Analysis of melatonin levels by ELISA kit. Values expressed in pg/ml
- Secondary Outcome Measures
Name Time Method Neurofilaments light chain levels (NFL) in cerebrospinal fluid Baseline Analysis of NFL levels by SIMOA kit. Values expressed in pg/ml
Orexin levels in cerebrospinal fluid Baseline Analysis of orexin levels by ELISA kit. Values expressed in ng/ml
Trial Locations
- Locations (1)
Istituto Auxologico Italiano - S. Giuseppe Hospital
🇮🇹Verbania, VB, Italy