Correlation Between Melatonin Levels in Different Biological Fluids

Recruiting

• Conditions: Neurodegenerative Diseases

• Registration Number: NCT05784090
• Lead Sponsor: Istituto Auxologico Italiano

Brief Summary

The goal of this observational study is to evaluate and to correlate melatonin levels in plasma, saliva and cerebrospinal fluid (CSF) samples of patients undergoing lumbar puncture diagnostic for specific neurological diseases.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-10-23
• Status Verified: 2023-03
• Study First Submitted: 2023-03-13
• Study First Submitted QC: 2023-03-13
• Last Update Submitted: 2023-03-13
• Study First Posted: 2023-03-24
• Last Update Posted: 2023-03-24
• Primary Completion: 2023-12-31
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• Neurodegenerative disease

Exclusion Criteria

• Age < 18 years
• Pregnancy
• Coagulations disorders
• Anticoagulant therapy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Melatonin levels in cerebrospinal fluid	Baseline	Analysis of melatonin levels by ELISA kit. Values expressed in pg/ml
Melatonin levels in plasma	Baseline	Analysis of melatonin levels by ELISA kit. Values expressed in pg/ml
Melatonin levels in saliva	Baseline	Analysis of melatonin levels by ELISA kit. Values expressed in pg/ml

Secondary Outcome Measures

Name	Time	Method
Neurofilaments light chain levels (NFL) in cerebrospinal fluid	Baseline	Analysis of NFL levels by SIMOA kit. Values expressed in pg/ml
Orexin levels in cerebrospinal fluid	Baseline	Analysis of orexin levels by ELISA kit. Values expressed in ng/ml

Trial Locations

Locations (1)

Istituto Auxologico Italiano - S. Giuseppe Hospital; 🇮🇹 Verbania, VB, Italy