跳至主要内容
临床试验/NCT06532214
NCT06532214招募中不适用

Clinical Retrospective Study Analysis of Postoperative Complications Following Hepatectomy

Nanfang Hospital, Southern Medical University1 个研究点 分布在 1 个国家目标入组 2,000 人开始时间: 2024年1月1日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
入组人数
2,000
试验地点
1
主要终点
Post-hepatectomy liver failure (PHLF)

研究概览

简要总结

Hepatectomy is a crucial surgical method for treating liver diseases such as liver cancer, hepatic hemangiomas, and biliary stones. Although hepatectomy has achieved significant therapeutic effects, postoperative complications remain an inevitable issue. Complications following hepatectomy include liver failure, hepatic vascular thrombosis, wound infection at the hepatic incision, and bile leakage, among others. These complications pose a serious threat to patients' health and life, and also increase the waste of medical resources and the cost of treatment. Currently, research on postoperative complications of hepatectomy mainly focuses on small sample studies from a single center, and most studies only focus on a specific complication, lacking comprehensive and systematic analysis. Therefore, it is necessary to conduct a retrospective study analysis of complications related to hepatectomy to more comprehensively and objectively understand the incidence, risk factors, prevention, and treatment of postoperative complications, providing clinical doctors with more scientific treatment plans and guidance.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients aged 18-80 years 2.Patients who underwent liver resection surgery at the participating centers

排除标准

  • Exclusion criteria are as follows:
  • Prior cancer treatments such as transarterial chemoembolization, ablation, or targeted therapy.
  • Repeat liver resection surgeries.
  • Presence of other malignancies.
  • Concurrent end-stage diseases including active infections, respiratory failure, decompensated heart failure, and autoimmune disease exacerbations.
  • Inadequate clinical data availability in medical records.

结局指标

主要结局

Post-hepatectomy liver failure (PHLF)

时间窗: On and after the 5th postoperative day

PHLF is commonly diagnosed and classified according to the criteria of the International Study Group for Liver Surgery (ISGLS), utilizing markers of liver function measured on or after postoperative day 5 (POD5).

次要结局

  • mortality(During 30 days after surgery)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

Loading locations...

相似试验