Randomized, three-group, parallel comparative study on changes in macular pigment optical density and visual function due to administration of supplements containing lutein and omega3 fatty acids to patients with age-related macular degeneration (patients treated with ranibizumab) - The comparative study on the effects of lutein and omega3 fatty acids supplements to age-related macular degeneration

The mean macular pigment optical density levels increased at month 12 compared to the baseline in all groups, but a statistically significant increase was observed only in group MMLD (multivitamins and minerals plus 12 mg lutein, p=0.023, Wilcoxon signed rank test). The mean frequency of retreatment was 2.6 in group MM ( multivitamins and minerals), 3.3 in group MML, and 1.6 in MMLD (multivitamins and minerals, plus lutein and 144 mg docosahexaenoic acid, p=0.338, Kruskal-Wallis test).