Impact of Genetic Drivers, Acquired Risk Factors, and Management Strategies on Survival and Clinical Outcomes in Visceral Venous Thrombosis
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 101
- 试验地点
- 1
- 主要终点
- Patients diagnosed with visceral venous thrombosis
研究概览
简要总结
This study aims to evaluate the impact of genetic drivers (somatic and inherited thrombophilias), acquired risk factors, and management strategies on survival and clinical outcomes in patients with VVT using a hybrid prospective-retrospective cohort design.
详细描述
Observational study (hybrid study comprising a retrospective and prospective cohort analysis):
To evaluate the impact of genetic drivers (somatic and inherited thrombophilias), acquired risk factors, and management strategies on survival and clinical outcomes in patients with VVT using a hybrid prospective-retrospective cohort design.
Data will be collected from the Department of Internal Medicine/hematology unit at Sohag University hospital and clinical databases.
The retrospective component will include eligible patients diagnosed within the preceding ten years, whereas the prospective component will enroll newly diagnosed patients and follow them for one year.
- Retrospective Cohort Analysis:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adult patients (≥ 18 years) with radiologically confirmed visceral venous thrombosis.
- •Availability of complete clinical, laboratory, and imaging data at diagnosis.
- •Patients who consent to participate and provide blood samples for genetic testing.
排除标准
- •Isolated lower-limb deep-vein thrombosis or pulmonary embolism without visceral involvement.
- •Patients with incomplete records precluding outcome assessment.
- •Refusal or inability to provide informed consent
- •Patients lost to follow-up within the first three months of diagnosis.
结局指标
主要结局
Patients diagnosed with visceral venous thrombosis
时间窗: The retrospective component will include eligible patients diagnosed within the preceding ten years, whereas the prospective component will enroll newly diagnosed patients and follow them for one year.
To evaluate the impact of genetic drivers (somatic and inherited thrombophilias), acquired risk factors, and management strategies on survival and clinical outcomes in patients with VVT using a hybrid prospective-retrospective cohort design.
次要结局
- Frequency and distribution(The retrospective component will include eligible patients diagnosed within the preceding ten years, whereas the prospective component will enroll newly diagnosed patients and follow them for one year.)
研究者
Fatma mohamed Ahmed Anwer
Principal Investigator
Sohag University