Comparison of oral ibuprofen versus acetaminophen in premature infants with patent ductus arteriosus
Not Applicable
- Conditions
- Patent ductus arteriosus.Patent ductus arteriosus
- Registration Number
- IRCT2015120425357N1
- Lead Sponsor
- Qazvin University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 106
Inclusion Criteria
Inclusion Criteria: Gestational age less than or equal to 34 weeks; Birth elapsed time less than or equal to 14 days; PDA diagnosis based on echocardiography findings.
Exclusion Criteria
Any type of congenital heart disease is to keep the blood flow needed PDA; Life-threatening infections; Grade 3-4 intraventricular hemorrhage (within recent 24 hours); Urinary output less than 1mg/kg/h in last 8 hours; Serum creatinine level higher than 88 µmol/L; platelet counts less than 109×50 per liter; Hyperbilirobinemia requiring blood transfusions; Active necrotizing enterocolitis or bowel perforation; Liver dysfunction; Gastrointestinal bleeding; Retinopathy; Bronchopulmonary dysplasia; Lack of parental consent.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Heart murmur. Timepoint: Before intervention - three days after the intervention. Method of measurement: Auscultation - Echocardiography.
- Secondary Outcome Measures
Name Time Method Bleeding Including the gastrointestinal tract, urinary tract and respiratory tract. Timepoint: During the intervention. Method of measurement: Clinical observation and tests such as analysis of urine and faeces.