Imaging of the aneurysmal wall using 7 Tesla MRI in unruptured intracranial aneurysms

Completed

Conditions: intracranial aneurysms
vascular abnormality in the head
10002363

Registration Number: NL-OMON41401

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 35

Inclusion Criteria

Patients of age 18 years or older capable of giving consent with an unruptured intracranial aneurysm who either need surgical clipping or endovascular treatment to treat the aneurysm or are followed through the outpatient department with routine follow-up imaging. Patients are available for scanning before possible treatment takes place.

Exclusion Criteria

Patients with an unruptured intracranial aneurysm who:
• are aged 18 years or younger
• are mentally or physically incapable of giving consent
• can not undergo MRI (claustrophobia, implants or metal objects in or around the body that can influence the scanning or can compromise the safety of the patient)
• have presence of a clip on or coils in another aneurysm
• have a fusiform, mycotic or traumatic unruptured aneurysm.
• are not able to understand Dutch or English written and/or spoken patient information
•Medical history of allergic reaction to gadolinium
•Patients with a medical history of impaired renal function (severe renal insufficiency, glomerular filtration rate (GFR) < 30 ml/min/1,73 m2; or nephrogenic systemic fibrosis/ nephrogenic fibrosing nephropathy (NSF/NFD)).

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To study whether the thickness and enhancement of the aneurysmal wall can be<br /><br>studied in patients with unruptured IA using 7.0 Tesla MRI. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary objective: to optimize the scanning protocol for visualization of<br /><br>enhancement of aneurysmal wall<br /><br><br /><br>Tertiary objective: To study whether differences in the thickness and<br /><br>enhancement of the aneurysmal wall exists between small unruptured aneurysms of<br /><br><= 7mm and large unruptured aneurysms >7mm in size.</p><br>