An Exploratory Study of HRD Score in Chinese Ovarian Cancer Patients Benefiting From PARP Inhibitor Targeted Therapy
- Conditions
- Ovarian Cancer
- Registration Number
- NCT05255861
- Lead Sponsor
- Xin Wu
- Brief Summary
This project intends to evaluate the sensitivity of different Homologous Recombination Deficiency (HRD) score to Poly(ADP-ribose) polymerase inhibitor (PARPi) by retrospectively analyzing the tissue samples of patients with ovarian cancer using PARPi, and to determine the cut off value of the HRD score algorithm suitable for the Chinese population, so as to provide evidence for the role of PARPi in ovarian cancer. The screening of the beneficiaries of maintenance therapy provides precise guidance and can be used as a reference for other cancer types.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- Female
- Target Recruitment
- 300
- age ≥ 18 years;
- high-grade serous/endometrioid epithelial ovarian cancer, fallopian tube cancer or primary peritoneal cancer;
- FIGO stage III or IV;
- at least 6 cycles and no more than 9 cycles First-line platinum-containing chemotherapy;
- CR or PR after chemotherapy;
- ECOG 0-1;
- sufficient biological samples for HRD score detection;
- patients signed informed consent;
- good bone marrow function.
- incomplete follow-up records of survival information;
- unqualified biological sample quality control
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Homologous Recombination Deficiency score After the ovarian tissue is obtained, an average of 3 year Optimize the Homologous Recombination Deficiency scoring algorithm to calculate the Homologous Recombination Deficiency score of each patient's ovarian cancer tissue
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
The Obstetrics and Gynecology Hospital of Fudan University
🇨🇳Shanghai, Shanghai, China