An observational study comparing neurocognitive function of obese patients with sleep disordered breathing with and without chronically elevated arterial carbon dioxide levels before and after 3 months of positive pressure mask therapy.

Sheila Sivam0 个研究点目标入组 60 人开始时间: 2015年2月11日最近更新: 2020年1月13日

适应症

试验速览

暂无简介。

•1.Age 18 – 75 years old
•2.Written informed consent
•3.Daytime CO2 > 45 (OHS) or < 45 (Control)
•4.Evidence of definite OSA on polysomnography, with an AHI >20 /hr OR evidence of sleep hypoventilation if AHI <20/hr
•*Increase in TcCO2 to a value > 55mmHg for >10 mins or
•*Increase in TcCO2 > 10 mmHg (compared with awake PaCO2) to a value > 50 mmHg for > 10 mins)
•5.BMI>40kg/m2
•6.pH is in the normal range for chronic hypercapnia
•7.FEV1/FVC ratio > 0.7

•1.Major psychiatric, neurological disorder or head injury
•2.Neuromuscular disease or lung disease
•3.FEV1/FVC ratio <0.7
•4.Uncontrolled medical conditions including cardiac failure
•5.Alcohol consumption >30 g/day or on medications potentially affecting cognitive testing or EEG recordings such as opiates, benzodiazepines, anti-depressants and anticonvulsants (unless on stable low dose).
•6.Not proficient in English

发起方

Sheila Sivam