Obesity Hypoventilation Syndrome and Neurocognitive Dysfunctio

Not Applicable

Completed

• Conditions: Obesity Hypoventilation Syndrome; Obstructive Sleep Apnoea; Respiratory - Sleep apnoea; Diet and Nutrition - Obesity

• Registration Number: ACTRN12615000122550
• Lead Sponsor: Sheila Sivam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-02-11
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1.Age 18 – 75 years old
2.Written informed consent
3.Daytime CO2 > 45 (OHS) or < 45 (Control)
4.Evidence of definite OSA on polysomnography, with an AHI >20 /hr OR evidence of sleep hypoventilation if AHI <20/hr

*Increase in TcCO2 to a value > 55mmHg for >10 mins or

*Increase in TcCO2 > 10 mmHg (compared with awake PaCO2) to a value > 50 mmHg for > 10 mins)

5.BMI>40kg/m2
6.pH is in the normal range for chronic hypercapnia
7.FEV1/FVC ratio > 0.7

Exclusion Criteria

1.Major psychiatric, neurological disorder or head injury
2.Neuromuscular disease or lung disease
3.FEV1/FVC ratio <0.7
4.Uncontrolled medical conditions including cardiac failure
5.Alcohol consumption >30 g/day or on medications potentially affecting cognitive testing or EEG recordings such as opiates, benzodiazepines, anti-depressants and anticonvulsants (unless on stable low dose).
6.Not proficient in English

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Psychomotor Vigilance Task (PVT)<br><br>[3 months after near normalization of carbon dioxide levels with positive airway pressure therapy (PAP)]