The effect of timolol gel on wound healing in patients with skin transplantatio
Phase 2
Recruiting
- Conditions
- Candidate Patients Receiving Skin Transplant.
- Registration Number
- IRCT20090613002027N18
- Lead Sponsor
- Sari University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Age =18 years of age
Undergoing a procedure which results in the need of a STSG
Willing to provide written informed consent
Exclusion Criteria
Pregnant women and breastfeeding
Use of systemic beta blockers drugs or topical except timolol
Hypersensitivity to timolol or other beta blockers
Severe, uncontrolled systemic comorbidities, such as diabetes, asthma, Chronic obstructive pulmonary disease
Use of systemic drugs that can impede wound healing, such retinoids or immune-suppressive drugs
Severe coagulation disorders including a lack of coagulation factors and immunologic thrombocytopenic purpura
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Duration of wound epithelization in donor site of the transplant. Timepoint: The evaluation of wound on days 0 and 3 and 7 and 14 after surgery. Method of measurement: Clinical observation regarding the wound epithelization.
- Secondary Outcome Measures
Name Time Method Pain severity. Timepoint: The evaluation times include days 0 (time of skin removal),3 ,7, 14 and 3 months after surgery. Method of measurement: Visual Analogue Scale.;?Evaluation of the scar status. Timepoint: Three months after surgery. Method of measurement: Vancouver Scar Scale (VSS) and The Patient and Observer Scar Assessment Scale (POSAS).