Comparison of Perioperative Analgesia Effectiveness Between Thoracolumbal Interfascial Plane Block With Erector Spinae Plane Block In Lumbar Posterior Decompression and Stabilization: A Study to Interleukin-6 and Interleukin-10 Plasma Concentration, Pain Scale, Total Opioid Consumption, and Cardiovascular Stability
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Lumbar Posterior Decompression
- Sponsor
- Indonesia University
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Change from baseline Interleukin-6 and Interleukin-10 at 6 hours after Lumbar Posterior Decompression and Stabilization
- Last Updated
- 4 years ago
Overview
Brief Summary
This study aimed to found out The Comparison Of Perioperative Analgesia Effectiveness Between Thoracolumbal Interfascial Plane Block with Erector Spinae Plane Block In Lumbar Posterior Decompression and Stabilization.
Detailed Description
This is a double blind randomized controlled trial. Forty subject will be recruited with non-probability consecutive sampling method. Subjects who meet all inclusion criteria and do not have exclusion criteria will be asked to sign the informed consent form before included in this study. Subjects will be randomized into two groups. The first group is the group who will get Bilateral Thoracolumbal Interfascial Plane Block after general anesthesia and the second group will be the group who will get Bilateral Erector Spinae Plane Block after general anesthesia. After surgery, pain scale, time to first morphine dose, total morphine consumption in 24 hours, cardiovascular stability and adverse events will be recorded for both group.
Investigators
Aida Rosita Tantri
Doctor
Indonesia University
Eligibility Criteria
Inclusion Criteria
- •Age 18 - 65 years old
- •Patients schedule for elective posterior decompression and stabilization lumbar spine surgery
- •ASA I - III
- •Decompression and posterior stabilization's patients who didn't caused by infection or abscess
Exclusion Criteria
- •Patients who refuse to participate in this study
- •Body Mass Index \< 18,5 kg/m2 and \> 27,0 kg/m2
- •Patient with history of chronic opioid
- •Patient with coagulation disorder
- •Patient with cognitive disorders
- •Infection at the injection area
Outcomes
Primary Outcomes
Change from baseline Interleukin-6 and Interleukin-10 at 6 hours after Lumbar Posterior Decompression and Stabilization
Time Frame: Before surgery and 6 hours after surgery
Measure by ELISA
Secondary Outcomes
- investigators will record total morphine dose needed in 24 hours(24 hours after surgery)