The Effect of Erythromycin on Occurrence of Leaks From Cervical Esophageal-Gastric Anastomosis After Trans-Hiatal Esophagectomy

Not Applicable

• Conditions: Esophagectomy; Postoperative Complications

• Registration Number: NCT00373919
• Lead Sponsor: Kaplan Medical Center

Brief Summary

Cervical anastomotic leak is one of the most common complications after trans-hiatal esophagectomy.

Hypothesis: An early post operative administration of a pro-kinetic dosage of erythromycin will reduce leak occurrence.

Design: This is a prospective, randomized, double blind, placebo controlled study.

Number of patients: 30.

Inclusion Criteria:

* Patients after trans-hiatal esophagectomy

Exclusion Criteria:

* Allergy to erythromycin

* Use of phenothiazine

* QT prolongation

* Liver function test (LFT) abnormalities

* Myasthenia gravis

* Cardiomyopathy

Detailed Description

Not available

Study Timeline

• Status Verified: 2006-08
• Study First Submitted: 2006-09-07
• Study First Submitted QC: 2006-09-07
• Study First Posted: 2006-09-08
• Last Update Submitted: 2007-03-02
• Last Update Posted: 2007-03-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Patients after trans-hiatal esophagectomy

Exclusion Criteria

• Allergy to erythromycin
• Use of phenothiazine
• QT prolongation
• Liver function test (LFT) abnormalities
• Myasthenia gravis
• Cardiomyopathy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL